(Q36473581)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

4

1 reference

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8 February 2020

Andreas Strasser

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

P N Kelly

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

S Grabow

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A R D Delbridge

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

20 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

57-63

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/cdd.2012.92

8 February 2020

exact match

0 references

cites work

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Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice

30 September 2017

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Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice.

30 September 2017

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Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

30 September 2017

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

30 September 2017

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Mcl-1 is essential for germinal center formation and B cell memory

30 September 2017

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Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

30 September 2017

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BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

30 September 2017

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The landscape of somatic copy-number alteration across human cancers

30 September 2017

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

30 September 2017

1 reference

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

30 September 2017

1 reference

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Mechanisms promoting translocations in editing and switching peripheral B cells

30 September 2017

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BCL-2 family antagonists for cancer therapy

30 September 2017

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Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

30 September 2017

1 reference

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In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

30 September 2017

1 reference

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Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

30 September 2017

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

30 September 2017

1 reference

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

30 September 2017

1 reference

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

30 September 2017

1 reference

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The BCL-2 protein family: opposing activities that mediate cell death

30 September 2017

1 reference

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Programmed anuclear cell death delimits platelet life span.

30 September 2017

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Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma

30 September 2017

1 reference

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

30 September 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

30 September 2017

1 reference

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Suppression of tumorigenesis by the p53 target PUMA

30 September 2017

1 reference

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Bim is a suppressor of Myc-induced mouse B cell leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

30 September 2017

1 reference

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

30 September 2017

1 reference

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The Bcl2 family: regulators of the cellular life-or-death switch

30 September 2017

1 reference

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Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

30 September 2017

1 reference

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Proliferation, cell cycle and apoptosis in cancer

30 September 2017

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

30 September 2017

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30 September 2017

The Hallmarks of Cancer

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

30 September 2017

1 reference

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Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival

30 September 2017

1 reference

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

30 September 2017

1 reference

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

30 September 2017

1 reference

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

30 September 2017

1 reference

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The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3524630

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 September 2018

2 references

https://api.crossref.org/works/10.1038%2FCDD.2012.92

21 January 2018

12 December 2020

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

2 references

https://api.crossref.org/works/10.1038%2FCDD.2012.92

21 January 2018

12 December 2020

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1 reference

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Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice

21 January 2018

1 reference

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Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

21 October 2018

1 reference

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Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

21 January 2018

1 reference

PubMed

12 December 2020

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/CDD.2012.92

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

22814621

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22814621%20AND%20SRC:MED&resulttype=core&format=json