(Q36474012)

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Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

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scholarly article

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28 February 2020

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26498406%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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neurodegeneration

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based on heuristic

inferred from title

Jau-Shyong Hong

3

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28 February 2020

author name string

Shih-Heng Chen

1

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28 February 2020

Esteban A Oyarzabal

2

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28 February 2020

publication date

26 October 2015

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28 February 2020

Current Opinion in Pharmacology

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28 February 2020

26

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28 February 2020

54-60

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Europe PubMed Central

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28 February 2020

The dynamics of monocytes and microglia in Alzheimer's disease

1 reference

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30 September 2017

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

1 reference

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30 September 2017

Neuroinflammation in Alzheimer's disease

1 reference

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30 September 2017

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models

1 reference

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30 September 2017

Ligand recognition specificity of leukocyte integrin αMβ2 (Mac-1, CD11b/CD18) and its functional consequences

1 reference

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30 September 2017

Microglial regulation of immunological and neuroprotective functions of astroglia

1 reference

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30 September 2017

Innate immune activation in neurodegenerative disease

1 reference

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30 September 2017

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

1 reference

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30 September 2017

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit

1 reference

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30 September 2017

Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis

1 reference

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30 September 2017

Reactive gliosis and the multicellular response to CNS damage and disease.

1 reference

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30 September 2017

Inflammasomes in the CNS.

1 reference

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30 September 2017

New insights on NOX enzymes in the central nervous system

1 reference

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30 September 2017

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

1 reference

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30 September 2017

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

1 reference

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30 September 2017

Mitochondria, oxidative stress and neurodegeneration.

1 reference

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30 September 2017

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

The neuroprotective effects of apocynin

1 reference

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30 September 2017

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Physiology of microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Evaluating the role of Toll-like receptors in diseases of the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

DAMPening inflammation by modulating TLR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Does neuroinflammation fan the flame in neurodegenerative diseases?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Immune activation in brain aging and neurodegeneration: too much or too little?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Fibrinogen signal transduction in the nervous system.

1 reference

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30 September 2017

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Toll-like receptors in neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Negative regulation of toll-like receptor-mediated immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Microglia and Macrophage Activation and the Regulation of Complement-Receptor-3 (CR3/MAC-1)-Mediated Myelin Phagocytosis in Injury and Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

30 September 2017

Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

1 reference

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30 September 2017

Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment

1 reference

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30 September 2017

Brain microglia constitutively express beta-2 integrins.

1 reference

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28 June 2018

NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation.

1 reference

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21 September 2018

Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection

1 reference

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21 September 2018

Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

1 reference

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21 September 2018

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

21 September 2018

Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4716876

21 September 2018

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

1 reference

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21 September 2018

Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils.

1 reference

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21 September 2018

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

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21 October 2018

MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26498406

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 upregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26498406

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.COPH.2015.10.001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26498406%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26498406%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26498406%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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