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NADPH oxidases: novel therapeutic targets for neurodegenerative diseases
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scholarly article
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Europe PubMed Central
PMC publication ID
3477578
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
title
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
main subject
neurodegeneration
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inferred from title
author
Jau-Shyong Hong
series ordinal
3
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Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
author name string
Hui-Ming Gao
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3477578
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
Hui Zhou
series ordinal
2
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Europe PubMed Central
PMC publication ID
3477578
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
publication date
11 April 2012
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3477578
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retrieved
28 January 2020
published in
Trends in Pharmacological Sciences
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Europe PubMed Central
PMC publication ID
3477578
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28 January 2020
volume
33
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stated in
Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
issue
6
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Europe PubMed Central
PMC publication ID
3477578
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28 January 2020
page(s)
295-303
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3477578
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28 January 2020
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Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
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The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators
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30 September 2017
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
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30 September 2017
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain
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Nox3 regulation by NOXO1, p47phox, and p67phox.
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Cognitive function in patients with chronic granulomatous disease: a preliminary report
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30 September 2017
Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase
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NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
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30 September 2017
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
30 September 2017
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
30 September 2017
Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
30 September 2017
NADPH oxidase activity is independent of p47phox in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
30 September 2017
Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
Expression and modulation of an NADPH oxidase in mammalian astrocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
29 June 2018
Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
The role of microglia in paraquat-induced dopaminergic neurotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Neurodegenerative diseases and oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Microglia promote the death of developing Purkinje cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Activation of NADPH oxidase in Alzheimer's disease brains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3477578
retrieved
22 September 2018
Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22503440
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22503440
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
NADPH oxidase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22503440
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22503440
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Distinct role of nitric oxide and peroxynitrite in mediating oligodendrocyte toxicity in culture and in experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22503440
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIPS.2012.03.008
1 reference
stated in
Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PMC publication ID
3477578
1 reference
stated in
Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PubMed publication ID
22503440
1 reference
stated in
Europe PubMed Central
PMC publication ID
3477578
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22503440%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
ResearchGate publication ID
224037235
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