(Q36492356)

14 August 2017

1 reference

title

Metal homeostasis in Alzheimer's disease (English)

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14 August 2017

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Anthony R White

1

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Ashley I. Bush

object named as

Ashley I Bush

series ordinal

3

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author name string

Kevin J Barnham

series ordinal

2

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14 August 2017

1 May 2006

1 reference

Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

14 August 2017

1 reference

14 August 2017

6

1 reference

14 August 2017

711-722

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14 August 2017

5

1 reference

Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities

14 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Zinc metabolism in the brain: relevance to human neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metals and amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metals, toxicity and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Alzheimer Disease and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Human alpha-fetoprotein as a Zn(2+)-binding protein. Tight cation binding is not accompanied by global changes in protein structure and stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Promotion of oxidative lipid membrane damage by amyloid beta proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

It all sticks together--the APP-related family of proteins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Evidence for Cu(II) reduction as a component of copper uptake by Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Zn(2+): a novel ionic mediator of neural injury in brain disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

The metallobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Inhibitory effect of copper(II) on zinc(II)-induced aggregation of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metallothionein III is reduced in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Structure and evolutionary aspects of matrix metalloproteinases: a brief overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Brain iron metabolism and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Iron and iron management proteins in neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Heme oxygenase-1: role in brain aging and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Aggregation of amyloid beta-protein and its neurotoxicity: enhancement by aluminum and other metals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Redox-active iron mediates amyloid-beta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Metal-protein attenuating compounds and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Intramuscular desferrioxamine in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Movement of zinc and its functional significance in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Diseasea

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.5.711

21 January 2018

Identifiers

DOI

10.1586/14737175.6.5.711

1 reference

14 August 2017

1 reference

PubMed ID

16734519