(Q36511471)

14 August 2017

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title

Designing nonviral vectors for efficient gene transfer and long-term gene expression (English)

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14 August 2017

3

Hans J Lipps

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14 August 2017

Dean A Jackson

1

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14 August 2017

Stefan Juranek

series ordinal

2

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14 August 2017

publication date

19 June 2006

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14 August 2017

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14 August 2017

volume

14

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14 August 2017

issue

5

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14 August 2017

page(s)

613-626

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

14 August 2017

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Progress and problems with the use of viral vectors for gene therapy

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Episomal vectors for gene expression in mammalian cells

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The LCR of EBV makes Burkitt's lymphoma endemic

7 January 2021

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Researchers and regulators reflect on first gene therapy death

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Gene therapy progress and prospects: cystic fibrosis

7 January 2021

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A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

7 January 2021

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Remote control of gene transcription

7 January 2021

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The principles of nuclear structure

7 January 2021

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ATP-dependent nucleosome remodeling

7 January 2021

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Histone and chromatin cross-talk

7 January 2021

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Translating the Histone Code

7 January 2021

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Chromosome territories, nuclear architecture and gene regulation in mammalian cells

7 January 2021

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Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions

7 January 2021

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Development of stable cell lines for production or regulated expression using matrix attachment regions

7 January 2021

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Activation by locus control regions?

7 January 2021

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Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

7 January 2021

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Looping and interaction between hypersensitive sites in the active beta-globin locus

7 January 2021

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The active spatial organization of the beta-globin locus requires the transcription factor EKLF

7 January 2021

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Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

7 January 2021

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Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

7 January 2021

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SATB1 targets chromatin remodelling to regulate genes over long distances

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The anatomy of transcription sites

7 January 2021

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The organization of replication and transcription

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The balance sheet for transcription: an analysis of nuclear RNA metabolism in mammalian cells

7 January 2021

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A structural perspective of CTD function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Elongation by RNA polymerase II: the short and long of it

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The nuclear lamina and its functions in the nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The nuclear lamina comes of age.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Nuclear lamins: building blocks of nuclear architecture

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Actin and hnRNP U cooperate for productive transcription by RNA polymerase II.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Visualization of a highly organized intranuclear network of filaments in living mammalian cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

F-actin-dependent insolubility of chromatin-modifying components

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Subchromosomal Positioning of the Epidermal Differentiation Complex (EDC) in Keratinocyte and Lymphoblast Interphase Nuclei

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Nuclear organization of mammalian genomes. Polar chromosome territories build up functionally distinct higher order compartments

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Nuclear organisation and gene expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Gene order and dynamic domains

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Replication timing and transcriptional control: beyond cause and effect

7 January 2021

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In search of the holy replicator

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Preventing re-replication of chromosomal DNA.

7 January 2021

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Stable chromosomal units determine the spatial and temporal organization of DNA replication.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Papillomavirus DNA replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Origin recognition and the chromosome cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

7 January 2021

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Origins of bidirectional replication of Epstein-Barr virus: models for understanding mammalian origins of DNA synthesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Improvement of nonviral gene therapy by Epstein-Barr virus (EBV)-based plasmid vectors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Herpes simplex virus type 1 amplicons and their hybrid virus partners, EBV, AAV, and retrovirus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

What they are, how they work and why they do what they do? The story of SV40-derived gene therapy vectors and what they have to offer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Towards safe, non-viral therapeutic gene expression in humans.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Chromosome-based vectors for gene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The structure and function of yeast ARS elements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Circular YAC vectors containing short mammalian origin sequences are maintained under selection as HeLa episomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Identification of a cis-element that determines autonomous DNA replication in eukaryotic cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Stability without a centromere

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Isolation of human sequences that replicate autonomously in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The potential of extrachromosomal replicating vectors for gene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Circular YAC vectors containing a small mammalian origin sequence can associate with the nuclear matrix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

An episomal mammalian replicon: sequence-independent binding of the origin recognition complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

An episomally replicating vector binds to the nuclear matrix protein SAF-A in vivo

7 January 2021

1 reference

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Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Mammalian genomes contain active recombinase recognition sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

A general model for site-specific recombination by the integrase family recombinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Construction of artificial chromosomes in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Artificial and engineered chromosomes: non-integrating vectors for gene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis

7 January 2021

1 reference

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Gene therapy progress and prospects: episomally maintained self-replicating systems.

7 January 2021

1 reference

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Neocentromeres and human artificial chromosomes: an unnatural act.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

A structurally defined mini-chromosome vector for the mouse germ line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Efficient male and female germline transmission of a human chromosomal vector in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Epstein-Barr virus vectors provide prolonged robust factor IX expression in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Short and highly efficient synthetic promoters for melanoma-specific gene expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The use of chromosome-based vectors for animal transgenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Recombinase-mediated gene activation and site-specific integration in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Stable gene expression from a mammalian artificial chromosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Functional complementation of a genetic deficiency with human artificial chromosomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Construction of human artificial chromosome vectors by recombineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Construction of a novel human artificial chromosome vector for gene delivery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Molecular and cytological analysis of a 5.5 Mb minichromosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Efficient transfer of chromosome-based DNA constructs into mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Efficient intracellular assembly of papillomaviral vectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Cellular transcription factor Sp1 recruits simian virus 40 capsid proteins to the viral packaging signal, ses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Enhancement of capsid gene expression: preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

BPV1 E2 protein enhances packaging of full-length plasmid DNA in BPV1 pseudovirions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Establishment of an oriP replicon is dependent upon an infrequent, epigenetic event

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

The DNA segregation mechanism of Epstein-Barr virus nuclear antigen 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2006.03.026

Chromosome engineering: prospects for gene therapy

7 January 2021

1 reference

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Origin and roles of nuclear matrix proteins. Specific functions of the MAR-binding protein MeCP2/ARBP.

7 January 2021

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10.1016/J.YMTHE.2006.03.026

7 January 2021

Identifiers

DOI

1 reference

14 August 2017

1 reference