(Q36524994)

English

Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)

scientific article published on 21 December 2012

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scholarly article

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Europe PubMed Central

14 August 2017

Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1) (English)

1 reference

Europe PubMed Central

14 August 2017

11

object named as

Yves Pommier

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14 August 2017

author name string

Martin Conda-Sheridan

1

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14 August 2017

P V Narasimha Reddy

2

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14 August 2017

Andrew Morrell

3

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14 August 2017

Brooklyn T Cobb

4

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14 August 2017

Christophe Marchand

5

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14 August 2017

Keli Agama

6

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14 August 2017

Adel Chergui

7

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14 August 2017

Amélie Renaud

8

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14 August 2017

Andrew G Stephen

9

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Europe PubMed Central

14 August 2017

Lakshman K Bindu

10

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14 August 2017

Mark Cushman

12

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publication date

21 December 2012

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14 August 2017

Journal of Medicinal Chemistry

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14 August 2017

56

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14 August 2017

182-200

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1

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14 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3542538/fullTextXML

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5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

1 reference

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Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors

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Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells

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Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

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Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.

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Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

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Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

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A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor

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Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

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Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings

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Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors

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The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

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The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

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DNA cleavage assay for the identification of topoisomerase I inhibitors

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Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I

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Benzannulation for the regiodefined synthesis of 2-alkyl/aryl-1-naphthols: total synthesis of arnottin I

1 reference

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Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1)

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Corrigendum to “Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores” [Bioorg. Med. Chem. 18 (2010) 182–189]

1 reference

https://pubmed.ncbi.nlm.nih.gov/23259865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM3014458

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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