(Q36529789)

14 August 2017

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title

Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms (English)

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14 August 2017

1 reference

John C Reed

1

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14 August 2017

1 July 2006

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Nature Clinical Practice Oncology

14 August 2017

1 reference

14 August 2017

3

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14 August 2017

7

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14 August 2017

388-398

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14 August 2017

Caspases and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Apoptosis-targeted therapies for cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Apoptosis-based therapies for hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Mechanisms of caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

IAP family proteins--suppressors of apoptosis

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

IAP proteins: blocking the road to death's door

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Deadly encounter: ubiquitin meets apoptosis

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Regulation of lymphocyte proliferation and death by FLIP.

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Mitochondrial control of cell death

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis.

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

The pathophysiology of mitochondrial cell death

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

The Bcl-2 family: roles in cell survival and oncogenesis.

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

The role of BH3-only proteins in the immune system

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Insights into programmed cell death through structural biology

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Estrogen withdrawal-induced human breast cancer tumour regression in nude mice is prevented by Bcl-2

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Retinoid targets for apoptosis induction

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Antisense oligonucleotide-based therapeutics for cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Identification of chelerythrine as an inhibitor of BclXL function

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Taming TRAIL: the winding path to a novel form of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Tumor necrosis factor-based isolated limb perfusion for soft tissue sarcoma and melanoma: ten years of successful antivascular therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

ATP binding to nucleotide binding domain (NBD)1 of the ClpB chaperone induces motion of the long coiled-coil, stabilizes the hexamer, and activates NBD2.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Structural biology. Controlling the caspases

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Non-peptidic small molecule inhibitors of XIAP

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

The Akt pathway: molecular targets for anti-cancer drug development

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0538

7 January 2021

Identifiers

DOI

10.1038/NCPONC0538

1 reference

14 August 2017

1 reference

PubMed ID

16826219