(Q34522855)

2 August 2017

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title

Deadly encounter: ubiquitin meets apoptosis (English)

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2 August 2017

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Veronika Jesenberger

1

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2 August 2017

Stefan Jentsch

series ordinal

2

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2 August 2017

publication date

1 February 2002

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Nature Reviews Molecular Cell Biology

2 August 2017

published in

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2 August 2017

volume

3

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2 August 2017

issue

2

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2 August 2017

page(s)

112-121

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2 August 2017

cites work

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Defying death after DNA damage.

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The morphology of apoptosis

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Life-or-death decisions by the Bcl-2 protein family.

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IAP family proteins--suppressors of apoptosis

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Selective protein degradation: a journey's end within the proteasome

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Mechanisms underlying ubiquitination

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Themes and variations on ubiquitylation

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Activation of polyubiquitin gene expression during developmentally programmed cell death

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The role of the ubiquitin-proteasome pathway in apoptosis

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Proteasomes in apoptosis: villains or guardians?

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Changes in the structure and function of the multicatalytic proteinase (proteasome) during programmed cell death in the intersegmental muscles of the hawkmoth, Manduca sexta

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SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

31 March 2020

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Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

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The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

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The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways

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The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis

31 March 2020

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Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

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Protective role of Raf-1 in Salmonella-induced macrophage apoptosis

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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

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p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

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Scythe: a novel reaper-binding apoptotic regulator.

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Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity

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Apoptosis induction resulting from proteasome inhibition

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Activation of the cell death program by inhibition of proteasome function

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Proteasomes play an essential role in thymocyte apoptosis

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Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

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Apoptosis and the proteasome.

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Down-regulation of beta-catenin by activated p53.

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Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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Regulation of PTEN transcription by p53

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

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Regulation and function of the p53 tumor suppressor protein

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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Mdm2 promotes the rapid degradation of p53

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Regulation of p53 stability by Mdm2

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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The MDM2 RING-finger domain is required to promote p53 nuclear export

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RB regulates the stability and the apoptotic function of p53 via MDM2

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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JNK targets p53 ubiquitination and degradation in nonstressed cells

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

31 March 2020

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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

31 March 2020

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X-linked IAP is a direct inhibitor of cell-death proteases

31 March 2020

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

31 March 2020

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A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors

31 March 2020

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RING finger proteins: mediators of ubiquitin ligase activity

31 March 2020

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

31 March 2020

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

31 March 2020

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

31 March 2020

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

31 March 2020

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Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.

31 March 2020

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Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis

31 March 2020

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

31 March 2020

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

31 March 2020

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IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

31 March 2020

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

31 March 2020

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

31 March 2020

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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

31 March 2020

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Inhibition of JNK activation through NF-kappaB target genes

31 March 2020

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Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

31 March 2020

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Control of apoptosis by Rel/NF-kappaB transcription factors

31 March 2020

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Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.

31 March 2020

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DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

31 March 2020

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NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death

31 March 2020

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Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

31 March 2020

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Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

31 March 2020

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Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

31 March 2020

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Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

31 March 2020

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31 March 2020

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Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

31 March 2020

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Advances in apoptosis research

31 March 2020

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

31 March 2020

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

31 March 2020

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

31 March 2020

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

31 March 2020

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Apoptosis in the nervous system

31 March 2020

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Signaling pathways in apoptosis as potential targets for cancer therapy

31 March 2020

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Series introduction: the transcription factor NF-kappaB and human disease

31 March 2020

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Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

31 March 2020

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Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

31 March 2020

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The Rel/NF-kappa B family: friend and foe.

31 March 2020

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Proteasome inhibitors: valuable new tools for cell biologists

31 March 2020

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

31 March 2020

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The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells

31 March 2020

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26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

31 March 2020

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM731

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Dimensions Publication ID

2 August 2017

1019261695

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