(Q36535802)

14 August 2017

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title

DNA damage checkpoints and cancer (English)

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14 August 2017

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Midori Shimada

1

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PubMed ID

16841236

14 August 2017

Makoto Nakanishi

series ordinal

2

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14 August 2017

14 July 2006

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Journal of Molecular Histology

14 August 2017

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14 August 2017

37

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14 August 2017

253-260

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14 August 2017

5-7

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Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

14 August 2017

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12 December 2020

Rapid destruction of human Cdc25A in response to DNA damage

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12 December 2020

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

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12 December 2020

Cell cycle checkpoint signaling through the ATM and ATR kinases

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12 December 2020

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

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12 December 2020

Protein modules that manipulate histone tails for chromatin regulation

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12 December 2020

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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12 December 2020

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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12 December 2020

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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12 December 2020

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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12 December 2020

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

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12 December 2020

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

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12 December 2020

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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12 December 2020

The role of p53 and pRB in apoptosis and cancer

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12 December 2020

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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12 December 2020

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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12 December 2020

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

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12 December 2020

MDC1 is required for the intra-S-phase DNA damage checkpoint

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12 December 2020

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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12 December 2020

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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12 December 2020

ATR and ATRIP: partners in checkpoint signaling

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12 December 2020

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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12 December 2020

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

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12 December 2020

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

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12 December 2020

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

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12 December 2020

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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12 December 2020

Cdk2-dependent and -independent pathways in E2F-mediated S phase induction

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12 December 2020

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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12 December 2020

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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12 December 2020

Mammalian G1- and S-phase checkpoints in response to DNA damage

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12 December 2020

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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12 December 2020

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12 December 2020

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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12 December 2020

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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12 December 2020

ATM-dependent phosphorylation of nibrin in response to radiation exposure

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12 December 2020

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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12 December 2020

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

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12 December 2020

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

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12 December 2020

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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12 December 2020

ATM and ataxia telangiectasia

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12 December 2020

A role for ATR in the DNA damage-induced phosphorylation of p53

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12 December 2020

ATM associates with and phosphorylates p53: mapping the region of interaction

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12 December 2020

A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin

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12 December 2020

Chromatin remodeling by ATP-dependent molecular machines.

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12 December 2020

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

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12 December 2020

The p53 and Mdm2 families in cancer.

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12 December 2020

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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12 December 2020

An epigenetic code for DNA damage repair pathways?

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12 December 2020

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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12 December 2020

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

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12 December 2020

Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.

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12 December 2020

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

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12 December 2020

ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex

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12 December 2020

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

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12 December 2020

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

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12 December 2020

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

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12 December 2020

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

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12 December 2020

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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12 December 2020

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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12 December 2020

CHK2 kinase--a busy messenger.

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12 December 2020

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

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12 December 2020

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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12 December 2020

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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12 December 2020

DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint.

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12 December 2020

MDC1 is a mediator of the mammalian DNA damage checkpoint

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12 December 2020

ATR and ATM regulate the timing of DNA replication origin firing

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12 December 2020

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

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12 December 2020

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

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12 December 2020

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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12 December 2020

A chromatin remodelling complex involved in transcription and DNA processing.

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12 December 2020

The histone code at DNA breaks: a guide to repair?

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12 December 2020

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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12 December 2020

Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair

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12 December 2020

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

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12 December 2020

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

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12 December 2020

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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12 December 2020

10.1007/S10735-006-9039-4

Identifiers

DOI

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14 August 2017

1 reference

PubMed ID

16841236