(Q36546250)

14 August 2017

1 reference

title

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies (English)

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14 August 2017

José V Castell

1

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14 August 2017

Ramiro Jover

series ordinal

2

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14 August 2017

Celia P Martínez-Jiménez

series ordinal

3

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14 August 2017

María José Gómez-Lechón

series ordinal

4

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14 August 2017

language of work or name

English

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publication date

1 April 2006

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Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

published in

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14 August 2017

volume

2

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14 August 2017

issue

2

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14 August 2017

page(s)

183-212

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Role of cytochromes P450 in drug metabolism and hepatotoxicity

14 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line

21 January 2018

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Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines

21 January 2018

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Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes

21 January 2018

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Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo

21 January 2018

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Functional human hepatocytes: isolation from small liver biopsy samples and primary cultivation with liver-specific functions

21 January 2018

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Inhibition and induction of human cytochrome P450 (CYP) enzymes

21 January 2018

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Induction of cytochrome P4501A1.

21 January 2018

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

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21 January 2018

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Pharmacogenetics - five decades of therapeutic lessons from genetic diversity

21 January 2018

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21 January 2018

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Interindividual variability in inhibition and induction of cytochrome P450 enzymes

21 January 2018

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

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Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines.

21 January 2018

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Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Rapid induction of NF-kappaB binding during liver cell isolation and culture: inhibition by L-NAME indicates a role for nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Recent advances in human hepatocyte culture systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Effects of ethanol and clofibrate on expression of cytochrome P-450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Regulation of the major detoxication functions by phenobarbital and 3-methylcholanthrene in co-cultures of rat hepatocytes and liver epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cryopreservation of adult human hepatocytes obtained from resected liver biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Report on the international workshop on the use of human in vitro liver preparations to study drug metabolism in drug development. Held at Utrecht, The Netherlands, 6-8 September 1994.

21 January 2018

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Progress in human hepatocytes: isolation, culture & cryopreservation.

21 January 2018

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Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Induction of cytochrome P450-dependent monooxygenase in serum-free cultured Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Examination of 7-ethoxycoumarin deethylation and ammonia removal activities in 31 hepatocyte cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Drug metabolising N-acetyltransferase activity in human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Infection of a human hepatoma cell line by hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Lipid-mediated transfection of normal adult human hepatocytes in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

SV40-induced immortalization and ras-transformation of human bronchial epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Precocious induction of tyrosine aminotransferase mRNA by hydrocortisone in cultured fetal rat hepatocytes at different developmental stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Human cell transformation by simian virus 40. Biologic features of cloned lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Carcinogen-induced diploid hepatocytes: sensitive target cells for transformation by mutated c-Ha-ras oncogene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalizing hepatocytes with truncated MET: a little bit of gene goes a long way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Treatment of surgically induced acute liver failure by transplantation of conditionally immortalized hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cell lines with heterogeneous phenotypes result from a single isolation of albumin-sv40 T-antigen transgenic rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Expression of c-fos and c-myc protooncogenes in an immortalized hepatocyte line harbouring SV40 T antigen and hGH as transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment and characterization of immortal hepatocytes derived from various transgenic mouse lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment of immortal hepatocytes from a CYP3A7-transgenic/p53-knockout mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Liver-specific physiology of immortal, functionally differentiated hepatocytes and of deficient hepatocyte-like variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A novel female-specific member of the CYP3A gene subfamily in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Gene expression in hepatocyte-like lines established by targeted carcinogenesis in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Microinjection of ADP-ribosylated actin inhibits actin synthesis in hepatocyte-hepatoma hybrid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cytochromes P450 expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulatio

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Regulation of a transcription factor network required for differentiation and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

HNF1, a homeoprotein member of the hepatic transcription regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The RXR heterodimers and orphan receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Structural basis for HNF-4alpha activation by ligand and coactivator binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Review of the in vivo functions of the p160 steroid receptor coactivator family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

DNA Methylation and Gene Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Sin meets NuRD and other tails of repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Roles of histone acetyltransferases and deacetylases in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The many HATs of transcription coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Coregulators and chromatin remodeling in transcriptional control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Bone marrow as a potential source of hepatic oval cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hematopoietic potential of stem cells isolated from murine skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Liver from bone marrow in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Origin and structural evolution of the early proliferating oval cells in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Out of Eden: stem cells and their niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Stem cell therapy of the liver--fusion or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Molecular basis of transdifferentiation of pancreas to liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Induction and regulation of acute phase proteins in transdifferentiated hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

In vitro hepatic differentiation of human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Generation of glycogen- and albumin-producing hepatocyte-like cells from embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Differentiation and isolation of hepatic-like cells from human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Generation of Hepatocyte-Like Cells from Human Embryonic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV40 LT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalization of epithelial-like cells from human liver tissue with SV40 T-antigen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalization of human fetal sinusoidal liver cells by polyoma virus large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hepatitis C virus core protein promotes immortalization of primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Xenobiotic-metabolizing enzyme activities in hybrid cell lines established by fusion of primary rat liver parenchymal cells with hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hematopoietic support and cytokine expression of murine-stable hepatocyte cell lines (MMH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Three new alternative splicing variants of human cytochrome P450 2D6 mRNA in human extratumoral liver tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

Hepatocytes from non-hepatic adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.2.183

21 January 2018

Identifiers

DOI

10.1517/17425255.2.2.183

1 reference

14 August 2017

1 reference