(Q36546738)

English

Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder

scientific article published on 24 October 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

myotonic dystrophy

1 reference

based on heuristic

inferred from title

object named as

Chun-Ho Wong

1

0 references

Tiziano Tuccinardi

object named as

Tiziano Tuccinardi

5

0 references

Steven Zimmerman

object named as

Steven C Zimmerman

7

0 references

Stacie L Richardson

2

object named as

Stacie L Richardson

1 reference

Europe PubMed Central

14 August 2017

PMC publication ID

author name string

Yen-Jun Ho

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Alex M H Lucas

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Anne M Baranger

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

publication date

24 October 2012

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

13

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

17

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

2505-2509

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Using modularly assembled ligands to bind RNA internal loops separated by different distances

1 reference

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Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)

1 reference

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In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models

1 reference

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A structural analysis of G-quadruplex/ligand interactions.

1 reference

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Bifacial nucleoside as a surrogate for both T and A in duplex DNA.

1 reference

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NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.

1 reference

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Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents

1 reference

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Relative substituent position on the strength of pi-pi stacking interactions

1 reference

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Repeat instability as the basis for human diseases and as a potential target for therapy

1 reference

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The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies

1 reference

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Pentamidine reverses the splicing defects associated with myotonic dystrophy.

1 reference

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A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.

1 reference

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Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

1 reference

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30 September 2017

Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549434

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Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.

1 reference

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Expandable DNA repeats and human disease.

1 reference

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Chemical modifiers of unstable expanded simple sequence repeats: what goes up, could come down

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549434

30 September 2017

The structural basis of myotonic dystrophy from the crystal structure of CUG repeats

1 reference

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Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s).

1 reference

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Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients

1 reference

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Chemically induced increases and decreases in the rate of expansion of a CAG*CTG triplet repeat

1 reference

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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

1 reference

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Trinucleotide repeats: mechanisms and pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549434

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Molecular recognition of DNA by small molecules

1 reference

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Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2

1 reference

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Helix geometry, hydration, and G.A mismatch in a B-DNA decamer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3549434

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Binding of 9-aminoacridine to bulged-base DNA oligomers from a frame-shift hot spot

1 reference

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Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

1 reference

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Zooming into pi-stacked manifolds of nucleobases: ionized states of dimethylated uracil dimers

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1 reference

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1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

Major groove accessibility of RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

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based on heuristic

inferred from PubMed ID database lookup

A reversal of misfortune for myotonic dystrophy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23097190

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/CBIC.201200602

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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