(Q36547790)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

review article

1 reference

title

Exploiting the p53 pathway for the diagnosis and therapy of human cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1

Lane DP

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

14 August 2017

language of work or name

1 reference

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

Cold Spring Harbor Symposia on Quantitative Biology

27 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

volume

70

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

page(s)

489-497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

27 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Pilot screening programme for small molecule activators of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

MDM2 is a central node in the p53 pathway: 12 years and counting

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Molecular characterization of the hdm2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Drosophila p53 binds a damage response element at the reaper locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Solution structure of p53 core domain: structural basis for its instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

p53: guardian AND suppressor of longevity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Activation of p53 in cervical carcinoma cells by small molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Identification and characterization of a p53 homologue in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Two genetic hits (more or less) to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

The human papillomavirus E6 protein and its contribution to malignant progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Core domain interactions in full-length p53 in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Clinical implications of p53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

A global map of p53 transcription-factor binding sites in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

The oligomerization domain of p53: Crystal structure of the trigonal form

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.049

21 January 2018

Identifiers

DOI

10.1101/SQB.2005.70.049

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869788%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference