(Q36558129)

14 August 2017

1 reference

title

Drugs targeting protein-protein interactions (English)

1 reference

protein-protein interaction

14 August 2017

1 reference

Patrick Chène

1

1 reference

14 August 2017

1 April 2006

1 reference

14 August 2017

1 reference

14 August 2017

1

1 reference

14 August 2017

400-411

1 reference

14 August 2017

4

1 reference

Dissecting subunit interfaces in homodimeric proteins

14 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

Stability of macromolecular complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

Transducible peptide therapy for uveal melanoma and retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

Efficient electrostatic solvation model for protein-fragment docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The ATPases: a new family for a family-based drug design approach

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

A map of the interactome network of the metazoan C. elegans

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Protein folding and quality control in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Diversity of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Principles of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The atomic structure of protein-protein recognition sites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Structural basis of macromolecular recognition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Structural characterisation and functional significance of transient protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Unraveling hot spots in binding interfaces: progress and challenges

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Dissecting protein-protein recognition sites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Protein-protein interfaces: architectures and interactions in protein-protein interfaces and in protein cores. Their similarities and differences

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Morphology of protein-protein interfaces.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Analysing six types of protein-protein interfaces

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Side-chain conformational entropy at protein-protein interfaces.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Binding in the growth hormone receptor complex

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Small molecule antagonists of proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The application of thermodynamic methods in drug design

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Molecular mechanism of the interaction between MDM2 and p53.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Molecular characterization of the hdm2-p53 interaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Aib-based peptide backbone as scaffolds for helical peptide mimics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600004

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600004

1 reference

14 August 2017

1 reference

PubMed ID

16892375