(Q36581944)

15 August 2017

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title

Bcl-2 family members and apoptosis, taken to heart (English)

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15 August 2017

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Asa B Gustafsson

1

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15 August 2017

Roberta A Gottlieb

series ordinal

2

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15 August 2017

publication date

30 August 2006

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American Journal of Physiology - Cell Physiology

15 August 2017

published in

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15 August 2017

volume

292

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15 August 2017

issue

1

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15 August 2017

page(s)

C45-51

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The Bcl-2 protein family: arbiters of cell survival

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

21 January 2018

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Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Calpain and mitochondria in ischemia/reperfusion injury

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Conversion of Bcl-2 to a Bax-like death effector by caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Modulation of cell death by Bcl-XL through caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Cell death: critical control points

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Left ventricular wall stress as a direct correlate of cardiomyocyte apoptosis in patients with severe dilated cardiomyopathy.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Reperfusion injury induces apoptosis in rabbit cardiomyocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

A unique pathway of cardiac myocyte death caused by hypoxia-acidosis.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Humanin peptide suppresses apoptosis by interfering with Bax activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Cytosolic heat shock protein 60, hypoxia, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

An essential role of the antioxidant gene Bcl-2 in myocardial adaptation to ischemia: an insight with antisense Bcl-2 therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Endonuclease G is an apoptotic DNase when released from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bid, but not Bax, regulates VDAC channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Puma joins the battery of BH3-only proteins that promote death and infarction during myocardial ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BID: a novel BH3 domain-only death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Regulation of sodium-calcium exchange and mitochondrial energetics by Bcl-2 in the heart of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

Chronic Hypoxia Induces Apoptosis in Cardiac Myocytes: A Possible Role for Bcl-2-like Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00229.2006

10.1152/AJPCELL.00229.2006

21 January 2018

Identifiers

DOI

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15 August 2017

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