(Q36583943)

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A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases.

scientific article published on January 2011

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5 February 2020

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Europe PubMed Central

A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases (English)

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5 February 2020

neurodegeneration

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Natalia Dudareva

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Natalia Dudareva

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5 February 2020

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Victoria I Bunik

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5 February 2020

John V Schloss

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5 February 2020

John T Pinto

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5 February 2020

Arthur J L Cooper

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1 January 2011

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5 February 2020

Advances in Enzymology and Related Areas of Molecular Biology

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5 February 2020

77

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5 February 2020

307-360

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5 February 2020

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1 reference

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A new perspective on the treatment of aromatic L-amino acid decarboxylase deficiency

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Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart

1 reference

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Structure and mechanism of inhibition of plant acetohydroxyacid synthase.

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Antenna domain mobility and enzymatic reaction of L-rhamnulose-1-phosphate aldolase

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Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins

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Protein-derived cofactors. Expanding the scope of post-translational modifications.

1 reference

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Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase

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The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale

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The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration

1 reference

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Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase

1 reference

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9 September 2017

A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase

1 reference

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9 September 2017

Carbon dioxide mediates Mn(II)-catalyzed decomposition of hydrogen peroxide and peroxidation reactions

1 reference

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9 September 2017

Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.

1 reference

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Structure and catalytic mechanism of L-rhamnulose-1-phosphate aldolase

1 reference

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Current status of metals as therapeutic targets in Alzheimer's disease

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Reaction and substrate specificity of recombinant pig kidney Dopa decarboxylase under aerobic and anaerobic conditions

1 reference

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1 reference

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2-Oxo acid dehydrogenase complexes in redox regulation

1 reference

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Natural and human-made mutagens and carcinogens in the human diet

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9 September 2017

The structure of L-rhamnulose-1-phosphate aldolase (class II) solved by low-resolution SIR phasing and 20-fold NCS averaging

1 reference

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Kinetic properties of the 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii evidence for the formation of a precatalytic complex with 2-oxoglutarate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

9 September 2017

Interaction of thioredoxins with target proteins: role of particular structural elements and electrostatic properties of thioredoxins in their interplay with 2-oxoacid dehydrogenase complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

9 September 2017

Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

9 September 2017

Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases

1 reference

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Caffeine-derived N-nitroso compounds. V. Carcinogenicity of mononitrosocaffeidine and dinitrosocaffeidine in bd-ix rats

1 reference

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9 September 2017

Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis

1 reference

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Reduced CO2/O2 specificity of ribulose-bisphosphate carboxylase/oxygenase in a temperature-sensitive chloroplast mutant of Chlamydomonas

1 reference

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Nucleotide sequence and deduced amino acid sequence of Escherichia coli pyruvate oxidase, a lipid-activated flavoprotein

1 reference

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Intermediates in reductive transacetylation catalyzed by pyruvate dehydrogenase complex

1 reference

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9 September 2017

Manganese(II) catalyzes the bicarbonate-dependent oxidation of amino acids by hydrogen peroxide and the amino acid-facilitated dismutation of hydrogen peroxide

1 reference

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9 September 2017

Paracatalytic modification of aldolase: A side reaction of the catalytic cycle resulting in irreversible blocking of two active-site lysyl residues

1 reference

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Irreversible Inactivation of Pyruvate Decarboxylase in the Presence of Substrate and an Oxidant. An Example of Paracatalytic Enzyme Inactivation

1 reference

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30 September 2017

Ribulose diphosphate carboxylase/oxygenase. III. Isolation and properties

1 reference

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Identification of an unusual [2Fe-2S]-binding motif in the CDP-6-deoxy-D-glycero-l-threo-4-hexulose-3-dehydrase from Yersinia pseudotuberculosis: implication for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses

1 reference

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1 reference

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Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

1 reference

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Ornithine and glutamate decarboxylases catalyse an oxidative deamination of their alpha-methyl substrates

1 reference

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Reaction specificity of native and nicked 3,4-dihydroxyphenylalanine decarboxylase

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Biotransformation of nitroso aromatic compounds and 2-oxo acids to N-hydroxy-N-arylacylamides by thiamine-dependent enzymes in rat liver.

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Direct mutagenicity of the polycylic aromatic hydrocarbon-containing fraction of smoked and charcoal-broiled foods treated with nitrite in acid solution

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Mechanism-based inactivation of dopa decarboxylase by serotonin.

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28 June 2018

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1 reference

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H2O2 oxidizes an aldolase dihydroxyacetone phosphate intermediate to hydroxymethylglyoxal phosphate

1 reference

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Effect of thiamine pyrophosphate and of the ions of divalent metals on the activity and stability of the alpha-ketoglutarate decarboxylase from the breast muscle of the pigeon

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Mechanistic probes for enzymic reactions. Oxidation-reduction indicators as oxidants of intermediary carbanions (studies with aldolase, aspartate aminotransferase, pyruvate decarboxylase, and 6-phosphogluconate dehydrogenase)

1 reference

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28 June 2018

Mutagenicities of nitrosated carboline derivatives

1 reference

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28 June 2018

Glutamate decarboxylase side reactions catalyzed by the enzyme

1 reference

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28 June 2018

Rapid inactivation of brain glutamate decarboxylase by aspartate

1 reference

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28 June 2018

Kinetics and specificity of reductive acylation of lipoyl domains from 2-oxo acid dehydrogenase multienzyme complexes.

1 reference

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28 June 2018

Oxygenase side reactions of acetolactate synthase and other carbanion-forming enzymes

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28 June 2018

Secondary amine precursors to nitrosamines in human saliva, gastric juice, blood, urine and faeces

1 reference

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28 June 2018

Oxidation of the carbanion intermediate of transaldolase by hexacyanoferrate (III).

1 reference

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28 June 2018

Specific irreversible inhibition of enzymes concomitant to the oxidation of carbanionic enzyme-substrate intermediates by hexacyanoferrate (III)

1 reference

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28 June 2018

5 Paracatalytic enzyme modification by oxidation of enzyme—substrate carbanion intermediates

1 reference

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28 June 2018

alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ

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20 September 2018

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20 September 2018

Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle.

1 reference

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20 September 2018

Purification and partial characterization of N-hydroxy-l-phenylalanine decarboxylase/oxidase from Bacillus sp. strain OxB-1, an enzyme involved in aldoxime biosynthesis in the "aldoxime-nitrile pathway".

1 reference

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20 September 2018

Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation.

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20 September 2018

PLP and PMP radicals: a new paradigm in coenzyme B6 chemistry

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20 September 2018

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1 reference

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20 September 2018

Affixing the O to Rubisco: discovering the source of photorespiratory glycolate and its regulation.

1 reference

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20 September 2018

A quinonoid is an intermediate of oxidative deamination reaction catalyzed by Dopa decarboxylase

1 reference

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20 September 2018

Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells

1 reference

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20 September 2018

Glutamate-mediated influx of extracellular Ca2+ is coupled with reactive oxygen species generation in cultured hippocampal neurons but not in astrocytes

1 reference

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20 September 2018

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

20 September 2018

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

20 September 2018

Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

20 September 2018

Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity.

1 reference

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20 September 2018

3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis

1 reference

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20 September 2018

Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase

1 reference

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20 September 2018

Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

1 reference

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20 September 2018

Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

20 September 2018

Oxygen-induced seizures and inhibition of human glutamate decarboxylase and porcine cysteine sulfinic acid decarboxylase by oxygen and nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563061

20 September 2018

Quo vadis photorespiration: a tale of two aldolases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-ornithine decarboxylase from Hafnia alvei has a novel L-ornithine oxidase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The macrokinetic behavior of an enzymatic system with an enzyme inactivated in the reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of glycolate by oxidation of the 1,2-dihydroxyethyl-thamin-diphosphate intermediate of transketolase with hexacyanoferrate(III) or H2O2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action of alpha-ketoglutarate dehydrogenase on 4-chloronitrosobenzene: evidence for species-dependent differences in active site properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ring substituents on the transketolase-catalyzed conversion of nitroso aromatics to hydroxamic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effect of chemical structure of chlorinated N-hydroxy-N-acyl-aminobiphenyl ethers and their related compounds on rat liver cytosol-catalyzed transacylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transition-state theoretical interpretation of the catalytic power of pyruvate decarboxylases: the roles of static and dynamical considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decarboxylation-dependent transamination catalyzed by mammalian 3,4-dihydroxyphenylalanine decarboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen Inhibition and Other Properties of Soybean Ribulose 1,5-Diphosphate Carboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the N-demethylation reactions catalyzed by horseradish peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paracatalytic inactivation of pig heart pyruvate dehydrogenase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate dehydrogenase complex-catalyzed formation of N-arylacetohydroxamic acids from nitroso aromatic compounds in rat isolated cells and perfused organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oxygenase reaction of acetolactate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of peroxidases with aromatic peracids and alkyl peroxides. Product analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of alpha-ketoglutarate dehydrogenase during its enzymatic reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Enzyme inactivation in the reaction process. Regulatory role]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of the carbanionic aldolase-substrate intermediate with tetranitromethane. Identification of the products, hydroxypyruvaldehyde phosphate and D-5-ketofructose 1,6-diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21692372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/9780470920541.CH7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21692372%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21692372%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21692372%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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