(Q36595702)

English

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

scientific article published on January 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Synaptotagmin 1 Dmel_CG3139

1 reference

GOA release 2020-03-11

Chantell S Evans

3

object named as

Chantell S Evans

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

7

object named as

Edwin R Chapman

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Amelia R Striegel

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Laurie M Biela

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Zhao Wang

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jillian B Delehoy

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

R Bryan Sutton

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Noreen E Reist

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 January 2012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

15 August 2017

32

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1253-1260

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

How synaptotagmin promotes membrane fusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Membrane binding and subcellular targeting of C2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Position of synaptotagmin I at the membrane interface: cooperative interactions of tandem C2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Electrostatic control of the membrane targeting of C2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Synaptotagmin I functions as a calcium regulator of release probability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

SNARE proteins contribute to calcium cooperativity of synaptic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

The C2 domain calcium-binding motif: structural and functional diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Synaptic transmission persists in synaptotagmin mutants of Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

9 September 2017

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

A role for synaptotagmin (p65) in regulated exocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Co-operative action a calcium ions in transmitter release at the neuromuscular junction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

28 June 2018

Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Nerve-evoked synchronous release and high K+ -induced quantal events are regulated separately by synaptotagmin I at Drosophila neuromuscular junctions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Drosophila synaptotagmin I null mutants survive to early adulthood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

20 September 2018

Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567453

4 December 2018

Calcium-dependent transmitter secretion from fibroblasts: modulation by synaptotagmin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/22279210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/22279210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22279210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/22279210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22279210

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4652-11.2012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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