(Q36617953)

15 August 2017

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis (English)

1 reference

15 August 2017

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Nuri A Temiz

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jaime Modiano

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Rama Khokha

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Richard G Gorlick

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

13

Aaron L Sarver

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

23

David A Largaespada

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1

Branden S Moriarity

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

3

Eric P Rahrmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

5

Natalie K Wolf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

4

Susan K Rathe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

George M Otto

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Madison T Weg

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Luke A Manlove

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Rebecca S LaRue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Sam D Molyneux

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Kwangmin Choi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Kevin J Holly

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Milcah C Scott

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Colleen L Forster

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Chand Khanna

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Yi Yang

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Michael A Dyer

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

0 references

publication date

11 May 2015

1 reference

15 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

615-624

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

11 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4767150/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A Comprehensive Guide to Sleeping Beauty-Based Somatic Transposon Mutagenesis in the Mouse

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Translational biology of osteosarcoma

30 September 2017

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ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway

30 September 2017

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CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma

30 September 2017

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microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R.

30 September 2017

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Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells

30 September 2017

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Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells

30 September 2017

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30 September 2017

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Proteomic identification of 14-3-3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells

30 September 2017

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PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice

30 September 2017

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SNARE-dependent interaction of Src, EGFR and β1 integrin regulates invadopodia formation and tumor cell invasion

30 September 2017

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miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

30 September 2017

1 reference

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Downregulation of microRNA-26a is associated with metastatic potential and the poor prognosis of osteosarcoma patients

30 September 2017

1 reference

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Tumor-suppressing effects of miR-141 in human osteosarcoma

30 September 2017

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MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.

30 September 2017

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Breed-predispositions to cancer in pedigree dogs.

30 September 2017

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Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

30 September 2017

1 reference

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Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration

30 September 2017

1 reference

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Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice

30 September 2017

1 reference

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Expression of p114RhoGEF predicts lymph node metastasis and poor survival of squamous-cell lung carcinoma patients

30 September 2017

1 reference

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miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma

30 September 2017

1 reference

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Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia

30 September 2017

1 reference

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Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma

30 September 2017

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The role of semaphorins and their receptors in gliomas

30 September 2017

1 reference

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TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data

30 September 2017

1 reference

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A meta-analysis of osteosarcoma outcomes in the modern medical era

30 September 2017

1 reference

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Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression.

30 September 2017

1 reference

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Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data.

30 September 2017

1 reference

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miRNA signatures associate with pathogenesis and progression of osteosarcoma

30 September 2017

1 reference

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Clonal selection drives genetic divergence of metastatic medulloblastoma

30 September 2017

1 reference

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YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma

30 September 2017

1 reference

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Suppression of bone formation by osteoclastic expression of semaphorin 4D

30 September 2017

1 reference

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Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray

30 September 2017

1 reference

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Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors

30 September 2017

1 reference

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Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways

30 September 2017

1 reference

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Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database

30 September 2017

1 reference

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Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment

30 September 2017

1 reference

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Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Osteosarcomagenesis: modeling cancer initiation in the mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Harnessing transposons for cancer gene discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Bone deposition, bone resorption, and osteosarcoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Metastasis: from dissemination to organ-specific colonization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Molecular characterization of the pediatric preclinical testing panel

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Critical role of notch signaling in osteosarcoma invasion and metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

CDH11 expression is associated with survival in patients with osteosarcoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

A review of clinical and molecular prognostic factors in osteosarcoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Management of childhood malignant peripheral nerve sheath tumor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Molecular pathogenesis of osteosarcoma.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

MET overexpression turns human primary osteoblasts into osteosarcomas.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Expression of bone morphogenetic proteins and receptors in sarcomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Repression of p53-dependent sequence-specific transactivation by MEF2c

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Aberrant ADAM10 expression correlates with osteosarcoma progression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Osteosarcoma: evolution of treatment paradigms

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Elevated expression of AKT2 correlates with disease severity and poor prognosis in human osteosarcoma

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Overexpression of fibroblast activation protein and its clinical implications in patients with osteosarcoma

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

MAPK7 and MAP2K4 as prognostic markers in osteosarcoma.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Parallel progression of primary tumours and metastases

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: involvement in tumor progression and metastasis.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767150

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNG.3293

The NF2 gene and merlin protein in human osteosarcomas

21 January 2018

1 reference

12 December 2020

Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma: the Japanese Musculoskeletal Oncology Group study

1 reference

12 December 2020

ErbB2 expression is correlated with increased survival of patients with osteosarcoma

1 reference

12 December 2020

Osteogenic sarcoma with clinically detectable metastasis at initial presentation

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Bone sarcomas arising in patients with neurofibromatosis type 1

1 reference

12 December 2020

Neurofibromatosis type 1, hyperparathyroidism, and osteosarcoma: interplay?

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.3293

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25961939%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

25961939

1 reference