(Q36697929)

English

The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

scientific article published on 22 February 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Elizabeth Cm de Lange

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

publication date

22 February 2013

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Fluids and Barriers of the CNS

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Europe PubMed Central

PMC publication ID

15 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

https://scigraph.springernature.com/pub.10.1186/2045-8118-10-12

0 references

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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Neuroendocrine response to antipsychotics: effects of drug type and gender.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Neurochemical changes in the aging human brain: implications for behavioral impairment and neurodegenerative disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Distributed model for drug delivery to CSF and brain tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Endosomes and Golgi vesicles in adsorptive and fluid phase endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Symposium on membrane transport. Transport in the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

The effects of some inhibitors and accelerators of sodium transport on the turnover of22Na in the cerebrospinal fluid and the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Transport of material between brain extracellular fluid, brain cells and blood.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Age-dependent activation of glucocorticoid receptors in the cerebral hemispheres of male rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

28 June 2018

Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Receptor occupancy and brain free fraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Comparison of species differences of P-glycoproteins in beagle dog, rhesus monkey, and human using Atpase activity assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Role of site-specific binding to plasma albumin in drug availability to brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Altered P-glycoprotein expression in AIDS patients with HIV encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Altered brain exposure of morphine in experimental meningitis studied with microdialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Alterations in striatal neuropeptide mRNA produced by repeated administration of L-DOPA, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Studies of cerebrospinal fluid flow and penetration into brain following lateral ventricle and cisterna magna injections of the tracer [14C]inulin in rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Drug-protein binding and blood-brain barrier permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

The pharmacokinetic principles behind scaling from preclinical results to phase I protocols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3602026

5 September 2018

Drug metabolizing enzymes in the brain and cerebral microvessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolactin release after remoxipride by an integrated pharmacokinetic-pharmacodynamic model with intra- and interindividual aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method for sequential sampling of cerebrospinal fluid in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and environmental sources of variation in heart rate response to infused nicotine in twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the binding of isradipine and darodipine to different plasma proteins on their transfer through the rat blood-brain barrier. Drug binding to lipoproteins does not limit the transfer of drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carrier-mediated or specialized transport of drugs across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and

1 reference

https://pubmed.ncbi.nlm.nih.gov/23432852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/2045-8118-10-12

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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