(Q36720868)

15 August 2017

1 reference

title

The concurrent chemoradiation paradigm--general principles (English)

1 reference

15 August 2017

0 references

3

Everett E Vokes

1 reference

15 August 2017

1

Tanguy Y Seiwert

1 reference

15 August 2017

Joseph K Salama

2

1 reference

15 August 2017

publication date

1 February 2007

1 reference

Nature Clinical Practice Oncology

15 August 2017

published in

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15 August 2017

volume

4

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15 August 2017

issue

2

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15 August 2017

page(s)

86-100

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The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced ce

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Phase III randomized trial of amifostine as a radioprotector in head and neck cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radioprotectants: current status and new directions

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Biological basis for chemo-radiotherapy interactions

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

A New Nonlinear Mixture Response Surface Paradigm for the Study of Synergism: A Three Drug Example

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Tumor hypoxia and anemia: impact on the efficacy of radiation therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Loss of local control with prolongation in radiotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

What is known about tumour proliferation rates to choose between accelerated fractionation or hyperfractionation?

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Molecular mechanisms of radiation-induced accelerated repopulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The radioresponsiveness of human tumours and the initial slope of the cell survival curve

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radioresistant laryngeal cancer: beyond the TNM stage

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Molecular markers as prognostic factors for local recurrence and radioresistance in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Cisplatin and radiation: interaction probabilities and therapeutic possibilities

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Production of DNA Double-Strand Breaks by Interactions between Carboplatin and Radiation: A Potential Mechanism for Radiopotentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Changes in X-ray Sensitivity of HeLa Cells during the Division Cycle

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Biologic basis for combining drugs with radiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Taxol and ionizing radiation: interaction and mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Lack of radiosensitization after paclitaxel treatment of three human carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Tumor microenvironmental physiology and its implications for radiation oncology

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Tumor reoxygenation as a mechanism of taxol-induced enhancement of tumor radioresponse

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Repopulation of cancer cells during therapy: an important cause of treatment failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The epidermal growth factor receptor mediates radioresistance.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Irradiation enhances cellular uptake of carboplatin

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radiopotentiation by the oral platinum agent, JM216: role of repair inhibition

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Cisplatin-modification of DNA repair and ionizing radiation lethality in yeast, Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Recent advances in the use of radiosensitizing nucleosides

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Fluorouracil: biochemistry and pharmacology

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The mechanism of action of radiosensitization of conventional chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Gemcitabine and radiosensitization in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Interaction of pemetrexed disodium (ALIMTA, multitargeted antifolate) and irradiation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radiosensitization by pemetrexed of human colon carcinoma cells in different cell cycle phases

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Taxol stabilizes microtubules in mouse fibroblast cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Cell synchronization unfortunately may not benefit cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Subadditive interaction of radiation and Taxol in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Mitomycin C in combination with radiotherapy as a potent inhibitor of tumour cell repopulation in a human squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Does tirapazamine (SR-4233) have any cytotoxic or sensitizing effect on three human tumour cell lines at clinically relevant partial oxygen pressure?

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The effect of the hypoxic cell drug SR-4233 alone or combined with the ionizing radiations on two human tumor cell lines having different radiosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Therapeutic advantage of hypoxic cells in tumors: a theoretical study

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Plasma and cerebrospinal fluid pharmacokinetics of intravenous temozolomide in non-human primates

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Promising survival and concomitant radiation plus temozolomide followed by adjuvant temozolomide

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Survival of human glioma cells treated with various combination of temozolomide and X-rays

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Intensity-modulated radiation therapy in gynecologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Epidermal growth factor receptor and signal transduction: potential targets for anti-cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Characterization of the amino acids essential for the photo- and radioprotective effects of a Bowman-Birk protease inhibitor-derived nonapeptide

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPONC0714

1 reference

7 January 2021

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Combined effects of angiostatin and ionizing radiation in antitumour therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Met, metastasis, motility and more

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Enhanced radiation damage of tumor vasculature by mTOR inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Rationale for chemoradiotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Where exactly does failure occur after radiation in head and neck cancer?

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Dose, time, volume relationships in squamous cell carcinoma of the supraglottic larynx

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Oxidative stress, redox, and the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Time factor and treatment strategies in subclinical disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0714

7 January 2021

Identifiers

DOI

10.1038/NCPONC0714

1 reference

15 August 2017

1 reference