(Q36725222)

15 August 2017

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title

Transporter-mediated drug interactions: clinical implications and in vitro assessment (English)

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15 August 2017

Jiunn H Lin

1

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

3

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15 August 2017

issue

1

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15 August 2017

page(s)

81-92

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Role of P-glycoprotein in pharmacokinetics: clinical implications

15 August 2017

cites work

1 reference

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Clinical relevance of P-glycoprotein in drug therapy

21 January 2018

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Transporters and xenobiotic disposition

21 January 2018

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Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport

21 January 2018

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

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Drug-drug interaction mediated by inhibition and induction of P-glycoprotein

21 January 2018

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P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil

21 January 2018

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Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

21 January 2018

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Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

21 January 2018

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Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

21 January 2018

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

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Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

21 January 2018

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

21 January 2018

1 reference

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Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

21 January 2018

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Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance

21 January 2018

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The effect of rifampin administration on the disposition of fexofenadine

21 January 2018

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Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

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Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

21 January 2018

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Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

21 January 2018

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HIV-1 protease inhibitors and the MDR1 multidrug transporter

21 January 2018

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Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and cerebrospinal fluid from patients infected with human immunodeficiency virus.

21 January 2018

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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

21 January 2018

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

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Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

21 January 2018

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

21 January 2018

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Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

21 January 2018

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Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

21 January 2018

1 reference

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

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Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

21 January 2018

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Pharmacokinetics of the penicillins in man

21 January 2018

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Effect of Chronic Probenecid Therapy on Cefazolin Serum Concentrations

21 January 2018

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Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

21 January 2018

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In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

21 January 2018

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Scientific perspectives on drug transporters and their role in drug interactions

21 January 2018

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Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.

21 January 2018

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Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

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Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Sense and nonsense in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.81

21 January 2018

Identifiers

DOI

10.1517/17425255.3.1.81

1 reference

15 August 2017

1 reference