(Q36727259)

English

Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage

scientific article published on 24 January 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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inferred from title

Darwin J Operario

4

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Darwin J Operario

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Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Varuni K Jamburuthugoda

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jose M Santos-Velazquez

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Mark Skasko

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Vandana Purohit

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Pauline Chugh

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Erika A Szymanski

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Joseph E Wedekind

8

1 reference

Europe PubMed Central

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15 August 2017

Robert A Bambara

9

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Europe PubMed Central

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15 August 2017

Baek Kim

10

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15 August 2017

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publication date

24 January 2008

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Europe PubMed Central

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15 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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15 August 2017

283

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Europe PubMed Central

PMC publication ID

15 August 2017

14

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

9206-9216

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect

1 reference

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Human immunodeficiency virus type 1: resistance to nucleoside analogues and replicative capacity in primary human macrophages.

1 reference

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L-nucleoside enantiomers as antivirals drugs: a mini-review.

1 reference

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Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases

1 reference

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30 September 2017

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

1 reference

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A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis

1 reference

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Mechanistic Understanding of an Altered Fidelity Simian Immunodeficiency Virus Reverse Transcriptase Mutation, V148I, Identified in a Pig-tailed Macaque

1 reference

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30 September 2017

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase

1 reference

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30 September 2017

Molecular architecture of the mutagenic active site of human immunodeficiency virus type 1 reverse transcriptase: roles of the beta 8-alpha E loop in fidelity, processivity, and substrate interactions

1 reference

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30 September 2017

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

1 reference

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30 September 2017

Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection

1 reference

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30 September 2017

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

1 reference

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30 September 2017

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

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30 September 2017

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

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30 September 2017

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

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30 September 2017

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

1 reference

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30 September 2017

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

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30 September 2017

DNA secondary structure effects on DNA synthesis catalyzed by HIV-1 reverse transcriptase

1 reference

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30 September 2017

The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase

1 reference

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30 September 2017

Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

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30 September 2017

Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

1 reference

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30 September 2017

Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.

1 reference

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30 September 2017

Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase

1 reference

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30 September 2017

Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

1 reference

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30 September 2017

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

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Physiological concentrations of purines and pyrimidines

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Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

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Conformational coupling in DNA polymerase fidelity

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Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

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Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

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High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

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Identification of four conserved motifs among the RNA-dependent polymerase encoding elements

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Origins and evolutionary relationships of retroviruses

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Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

1 reference

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21 January 2018

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Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations

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Mechanistic role of residue Gln151 in error prone DNA synthesis by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Pre-steady state kinetic study of the Q151N HIV-1 RT mutant with increased fidelity

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Identifiers

10.1074/JBC.M710149200

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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