(Q36822443)

16 August 2017

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title

Therapeutic potential of drugs to modulate DNA repair in cancer (English)

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16 August 2017

Nicola Curtin

1

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16 August 2017

language of work or name

English

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publication date

1 June 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

published in

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16 August 2017

volume

11

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16 August 2017

issue

6

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16 August 2017

page(s)

783-799

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Genome maintenance mechanisms for preventing cancer

16 August 2017

cites work

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

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Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

21 January 2018

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Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

21 January 2018

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Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy

21 January 2018

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Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study

21 January 2018

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Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

21 January 2018

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

21 January 2018

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Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy

21 January 2018

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O6-alkylguanine-DNA alkyltransferase inactivation in cancer chemotherapy.

21 January 2018

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MGMT: its role in cancer aetiology and cancer therapeutics

21 January 2018

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Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) polymerase: a molecular nick-sensor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.6.783

XRCC1 and DNA strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Involvement of poly(ADP-ribose) polymerase in base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

PARP inhibitors for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Chemopotentiation by PARP inhibitors in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose)polymerase inhibition - where now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Involvement of Poly (ADP-ribose) in the Radiation Response of Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Integrating genetic approaches into the discovery of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Targeting the double-strand DNA break repair pathway as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Inhibition of poly(ADP-ribose) polymerase in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Pathways of DNA double-strand break repair during the mammalian cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Repair of DNA double strand breaks by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

(ADP-ribose)n participates in DNA excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.6.783

10.1517/14728222.11.6.783

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference