(Q36827084)

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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling

scientific article published on April 2013

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling (English)

1 reference

Europe PubMed Central

16 August 2017

Scott A Summers

9

object named as

Scott A Summers

1 reference

Europe PubMed Central

16 August 2017

author name string

Monowarul M Siddique

1

1 reference

Europe PubMed Central

16 August 2017

Ying Li

2

1 reference

Europe PubMed Central

16 August 2017

Liping Wang

3

1 reference

Europe PubMed Central

16 August 2017

Jianhong Ching

4

1 reference

Europe PubMed Central

16 August 2017

Mainak Mal

5

1 reference

Europe PubMed Central

16 August 2017

Olga Ilkayeva

6

1 reference

Europe PubMed Central

16 August 2017

Ya Jun Wu

7

1 reference

Europe PubMed Central

16 August 2017

Boon Huat Bay

8

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Europe PubMed Central

16 August 2017

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publication date

1 April 2013

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Europe PubMed Central

16 August 2017

Molecular and Cellular Biology

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Europe PubMed Central

16 August 2017

33

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Europe PubMed Central

16 August 2017

11

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Europe PubMed Central

16 August 2017

2353-2369

1 reference

Europe PubMed Central

16 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3648062/fullTextXML

based on heuristic

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Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

1 reference

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AMP-activated protein kinase: a target for drugs both ancient and modern

1 reference

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29 September 2017

Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Regulation of lipid stores and metabolism by lipophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex

1 reference

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29 September 2017

A ceramide-centric view of insulin resistance

1 reference

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29 September 2017

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

1 reference

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Thiazolidinediones and PPARγ agonists: time for a reassessment

1 reference

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29 September 2017

Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis

1 reference

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29 September 2017

AMPK: a nutrient and energy sensor that maintains energy homeostasis

1 reference

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29 September 2017

Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

1 reference

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29 September 2017

Sphingolipids and hepatic steatosis

1 reference

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29 September 2017

Thiazolidinediones and type 2 diabetes: from cellular targets to cardiovascular benefit

1 reference

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29 September 2017

Akt signalling in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Functions of autophagy in hepatic and pancreatic physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Autophagy in nonalcoholic steatohepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Interplay between FOXO, TOR, and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Akt, FoxO and regulation of apoptosis

1 reference

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29 September 2017

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Sensing of energy and nutrients by AMP-activated protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide starves cells to death by downregulating nutrient transporter proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide in apoptosis: an overview and current perspectives

1 reference

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29 September 2017

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

1 reference

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29 September 2017

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Cellular survival: a play in three Akts

1 reference

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29 September 2017

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

29 September 2017

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

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Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading.

1 reference

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29 September 2017

Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

27 June 2018

Ceramide activates heterotrimeric protein phosphatase 2A.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

27 June 2018

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.

1 reference

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5 September 2018

Ceramide-induced starvation triggers homeostatic autophagy

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5 September 2018

Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice

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5 September 2018

Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

5 September 2018

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

5 September 2018

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5 September 2018

Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648062

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Induction of autophagy by amino-acid deprivation in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23547262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt is more than just a Bad kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23547262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR activators and gastroenterology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23547262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23547262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.00226-13

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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