(Q36877317)

16 August 2017

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title

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling (English)

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16 August 2017

Michael L Dustin

2

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author name string

Adam Mor

series ordinal

1

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16 August 2017

Mark R Philips

series ordinal

3

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16 August 2017

publication date

1 August 2007

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16 August 2017

published in

Immunological Reviews

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16 August 2017

volume

218

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16 August 2017

page(s)

114-125

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Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells

16 August 2017

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21 January 2018

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ICAM-1 co-stimulates target cells to facilitate antigen presentation

21 January 2018

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Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes

21 January 2018

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Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion.

21 January 2018

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

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Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion

21 January 2018

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

21 January 2018

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Remote T cell co-stimulation via LFA-1/ICAM-1 and CD2/LFA-3: Demonstration with immobilized ligand/mAb and implication in monocyte-mediated co-stimulation

21 January 2018

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Inhibition of T cell activation with a humanized anti-beta 1 integrin chain mAb.

21 January 2018

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LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells

21 January 2018

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The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

21 January 2018

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GTPases in antigen receptor signalling

21 January 2018

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T-cell integrins: more than just sticking points

21 January 2018

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Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1.

21 January 2018

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Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

21 January 2018

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Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

21 January 2018

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All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

21 January 2018

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Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

21 January 2018

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Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.

21 January 2018

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Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.

21 January 2018

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

1 reference

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Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes

21 January 2018

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Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells

21 January 2018

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Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression

21 January 2018

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LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds

21 January 2018

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Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

21 January 2018

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Ras pathway signaling on endomembranes

21 January 2018

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Rap1 GTPase: Functions, Regulation, and Malignancy

21 January 2018

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Membranes as messengers in T cell adhesion signaling

21 January 2018

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Cell spreading and lamellipodial extension rate is regulated by membrane tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

21 January 2018

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CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

21 January 2018

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Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

21 January 2018

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Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

21 January 2018

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Structural basis of integrin activation by talin

21 January 2018

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SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

21 January 2018

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Coupling of the TCR to integrin activation by Slap-130/Fyb.

21 January 2018

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ADAP-ting TCR signaling to integrins

21 January 2018

1 reference

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Rap1 regulation of RIAM and cell adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

A new member of the immunoglobulin superfamily--CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

A molecular perspective of CTLA-4 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

21 January 2018

1 reference

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Rho-GTPases: new members, new pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Integrin-mediated signals regulated by members of the rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Activation of Rac and Cdc42 by integrins mediates cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Roles for Rho/ROCK and vinculin in parietal endoderm migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Vav-family proteins in T-cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Calcium signaling through the beta 2-cytoplasmic domain of LFA-1 requires intracellular elements of the T cell receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

Phosphorylation of the LFA-1 Integrin β2-Chain on Thr-758 Leads to Adhesion, Rac-1/Cdc42 Activation, and Stimulation of CD69 Expression in Human T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2007.00538.X

10.1111/J.1600-065X.2007.00538.X

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference