(Q36892623)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

review article

1 reference

title

Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

language of work or name

English

0 references

publication date

1 September 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

volume

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

page(s)

906-911

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17654739%20AND%20SRC:MED&resulttype=core&format=json

Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

2 January 2020

cites work

1 reference

The expression of antiapoptotic proteins Bcl-2, Bcl-X(L), and Mcl-1 in benign, dysplastic, and malignant biliary epithelium

21 January 2018

1 reference

Detection of bcl-2 and bax expression and bcl-2/JH fusion gene in intrahepatic cholangiocarcinoma

21 January 2018

1 reference

Survival and apoptosis: a dysregulated balance in liver cancer

21 January 2018

1 reference

7 January 2021

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

1 reference

7 January 2021

Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

1 reference

7 January 2021

Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells

1 reference

7 January 2021

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

1 reference

7 January 2021

Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes

1 reference

7 January 2021

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

7 January 2021

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

1 reference

7 January 2021

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

1 reference

7 January 2021

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

7 January 2021

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

7 January 2021

BID: a novel BH3 domain-only death agonist

1 reference

7 January 2021

A stapled BID BH3 helix directly binds and activates BAX

1 reference

7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

7 January 2021

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

7 January 2021

bcl-2 protein in non-small-cell lung carcinoma

1 reference

7 January 2021

Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family

1 reference

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

7 January 2021

Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer

1 reference

7 January 2021

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.

1 reference

7 January 2021

Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies.

1 reference

7 January 2021

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

7 January 2021

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

7 January 2021

Bim is a suppressor of Myc-induced mouse B cell leukemia

1 reference

7 January 2021

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

1 reference

7 January 2021

Suppression of tumorigenesis by the p53 target PUMA

1 reference

7 January 2021

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.

1 reference

7 January 2021

Expression and role of Bcl-xL in human hepatocellular carcinomas

1 reference

7 January 2021

Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy

1 reference

7 January 2021

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

1 reference

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

7 January 2021

c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner

1 reference

7 January 2021

Restoring cancer's death sentence

1 reference

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

7 January 2021

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

1 reference

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

7 January 2021

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 reference

7 January 2021

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

1 reference

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

7 January 2021

A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

1 reference

7 January 2021

The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

1 reference

7 January 2021

Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

1 reference

7 January 2021

COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells

1 reference

7 January 2021

Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma

1 reference

7 January 2021

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

1 reference

7 January 2021

Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells

1 reference

7 January 2021

A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

1 reference

7 January 2021

Programmed anuclear cell death delimits platelet life span.

1 reference

7 January 2021

Bcl-XL Mutations Suppress Cellular Sensitivity to Antimycin A

1 reference

7 January 2021

mir-29 regulates Mcl-1 protein expression and apoptosis

1 reference

7 January 2021

Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, Fas, Lewis(y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas

1 reference

7 January 2021

Immunohistochemical analysis of pro-apoptotic Bid level in chronic hepatitis, hepatocellular carcinoma and liver metastases.

1 reference

7 January 2021

Expression of Bcl-2 family modulated through p53-dependent pathway in human hepatocellular carcinoma

1 reference

7 January 2021

Downregulation of proapoptotic proteins Bax and Bcl-X(S) in p53 overexpressing hepatocellular carcinomas

1 reference

7 January 2021

The associated expression of Maspin and Bax proteins as a potential prognostic factor in intrahepatic cholangiocarcinoma

1 reference

7 January 2021

Protein Explorer: easy yet powerful macromolecular visualization.

1 reference

7 January 2021