(Q36911406)

17 August 2017

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title

Small molecule inhibitors of Abeta assembly (English)

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17 August 2017

Harry LeVine

1

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17 August 2017

publication date

1 September 2007

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17 August 2017

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17 August 2017

volume

14

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17 August 2017

issue

3

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17 August 2017

page(s)

185-197

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Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

17 August 2017

cites work

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Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

21 January 2018

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The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly

21 January 2018

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Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration

21 January 2018

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Protein aggregation in Alzheimer's disease and other neoropathological disorders

21 January 2018

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

21 January 2018

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Cell toxicity and conformational disease.

21 January 2018

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Protein conformational diseases: from mechanisms to drug designs

21 January 2018

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

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Modeling Alzheimer's disease and other proteopathies in vivo: is seeding the key?

21 January 2018

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The cerebral proteopathies

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Staging of Alzheimer's disease-related neurofibrillary changes

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Screening for inhibitors of tau polymerization

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Current strategies for the treatment of Alzheimer's disease and other tauopathies

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Kinetics and thermodynamics of amyloid fibril assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Polymerization of proteins into amyloid protofibrils shares common critical oligomeric states but differs in the mechanisms of their formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Assembly of amyloid protofibrils via critical oligomers--a novel pathway of amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

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https://api.crossref.org/works/10.1080%2F13506120701461020

Cerebral amyloid angiopathy: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Neurotoxic protein oligomers--what you see is not always what you get.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Structural basis of protein kinetic stability: resistance to sodium dodecyl sulfate suggests a central role for rigidity and a bias toward beta-sheet structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Femtomole Immunodetection of Synthetic and Endogenous Amyloid-β Oligomers and Its Application to Alzheimer's Disease Drug Candidate Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Conformational Abs recognizing a generic amyloid fibril epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Humoral Immune Response to Fibrillar β-Amyloid Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Biotin-avidin interaction-based screening assay for Alzheimer's beta-peptide oligomer inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Structure of the cross-beta spine of amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Recent atomic models of amyloid fibril structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Structures for amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Dissecting the assembly of Abeta16-22 amyloid peptides into antiparallel beta sheets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloidogenesis: historical and modern observations point to heparan sulfate proteoglycans as a major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Crucial role of heparan sulfate proteoglycan (agrin) in beta-amyloid formation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Novel glycosaminoglycan precursors as antiamyloid agents: Part IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Screening for pharmacologic inhibitors of amyloid fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A beta deposition inhibitor screen using synthetic amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Structural properties of Abeta protofibrils stabilized by a small molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Specific plasma membrane binding sites for polyphenols, including resveratrol, in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Growth of beta-amyloid(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Screening for modulators of aggregation with a microplate elongation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Deposition of soluble amyloid-beta onto amyloid templates: with application for the identification of amyloid fibril extension inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Analysis of protein aggregation kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Modified-peptide inhibitors of amyloid beta-peptide polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Peptide-based inhibitors of amyloid assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

New heterocyclic beta-sheet ligands with peptidic recognition elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Prevention of Alzheimer's disease-associated Abeta aggregation by rationally designed nonpeptidic beta-sheet ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Anti-Parkinsonian agents have anti-amyloidogenic activity for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A hybrid molecule that prohibits amyloid fibrils and alleviates neuronal toxicity induced by beta-amyloid (1-42)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Inhibition of Alzheimer beta-fibrillogenesis by melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Nicotine and amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Both the D-(+) and L-(-) enantiomers of nicotine inhibit Abeta aggregation and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Abeta aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Anti-amyloidogenic activity of tetracyclines: studies in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

[34] X-Ray fiber diffraction of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120701461020

10.1080/13506120701461020

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference