(Q36925565)

17 August 2017

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title

Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity (English)

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17 August 2017

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Roberto Cappai

1

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17 August 2017

Kevin J Barnham

series ordinal

2

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17 August 2017

publication date

31 August 2007

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17 August 2017

published in

Neurochemical Research

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17 August 2017

volume

33

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17 August 2017

issue

3

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17 August 2017

page(s)

526-532

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https://scigraph.springernature.com/pub.10.1007/s11064-007-9469-8

17 August 2017

exact match

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cites work

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p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

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Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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12 December 2020

Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists

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12 December 2020

The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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12 December 2020

Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines

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12 December 2020

Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration

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12 December 2020

ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

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12 December 2020

Metal catalyzed oxidation of tyrosine residues by different oxidation systems of copper/hydrogen peroxide

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12 December 2020

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

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12 December 2020

Rapid characterization of amyloid-beta side-chain oxidation by tandem mass spectrometry and the scoring algorithm for spectral analysis

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12 December 2020

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

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12 December 2020

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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12 December 2020

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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12 December 2020

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

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12 December 2020

Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists.

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12 December 2020

Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine

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12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

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12 December 2020

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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12 December 2020

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

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12 December 2020

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

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12 December 2020

Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides

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12 December 2020

Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35).

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12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

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12 December 2020

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

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12 December 2020

Interaction of beta-amyloid peptides with integrins in a human nerve cell line

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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12 December 2020

1,1'-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: a new potential copper chelator agent for neuroprotection in Alzheimer's disease. Its comparative effects with clioquinol on rat brain copper distribution.

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12 December 2020

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

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12 December 2020

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

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12 December 2020

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

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12 December 2020

Regulation of NMDA receptor trafficking by amyloid-beta

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12 December 2020

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.

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12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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12 December 2020

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

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12 December 2020

Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease?

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12 December 2020

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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12 December 2020

Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein

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12 December 2020

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

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12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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12 December 2020

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

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12 December 2020

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

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12 December 2020

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

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12 December 2020

Methionine regulates copper/hydrogen peroxide oxidation products of Abeta

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12 December 2020

Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

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12 December 2020

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

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12 December 2020

In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress

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12 December 2020

Alzheimer's disease and Abeta toxicity: from top to bottom

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12 December 2020

Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis

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12 December 2020

Synaptic plasticity: one STEP at a time

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

Redox properties of Met(35) in neurotoxic beta-amyloid peptide. A molecular modeling study

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12 December 2020

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: implications for therapeutic strategies against amyloidosis

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12 December 2020

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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12 December 2020

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

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12 December 2020

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.

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12 December 2020

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

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12 December 2020

Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo

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12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

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12 December 2020

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12 December 2020

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Ultrastructural localization of intraneuronal Abeta-peptide in Alzheimer disease brains

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12 December 2020

Diversity of amyloid beta protein fragment [1-40]-formed channels.

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12 December 2020

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide

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12 December 2020

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease

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12 December 2020

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

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12 December 2020

Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

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12 December 2020

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

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12 December 2020

Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?

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12 December 2020

10.1007/S11064-007-9469-8

Identifiers

DOI

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17 August 2017

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