(Q36940130)

17 August 2017

1 reference

title

Activation of G protein-coupled receptors (English)

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G protein-coupled receptor

17 August 2017

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2

Brian Kobilka

1 reference

17 August 2017

Xavier Deupi

1

1 reference

17 August 2017

1 January 2007

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Advances in Protein Chemistry

17 August 2017

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17 August 2017

74

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17 August 2017

137-166

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Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: a site-directed spin-labeling study

17 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Fingerprinting G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Orphan G-protein-coupled receptors and natural ligand discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

G protein-coupled receptors. I. Diversity of receptor-ligand interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Linking agonist binding to histamine H1 receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Efficacy at G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Ligand-selective receptor conformations revisited: the promise and the problem

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The Three-dimensional Structure of Bovine Rhodopsin Determined by Electron Cryomicroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The two-state model of receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Transduction of receptor signals by beta-arrestins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure of bovine rhodopsin in a trigonal crystal form.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

X-ray crystallographic studies for ligand-protein interaction changes in rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Lessons from constitutively active mutants of G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Phototransduction: crystal clear

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Electron crystallography reveals the structure of metarhodopsin I.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structure of rhodopsin and the metarhodopsin I photointermediate.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Projection structure of rhodopsin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

G protein mechanisms: insights from structural analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural basis of beta-adrenergic receptor function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Common and differential mechanisms of gonadotropin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974004-4

7 January 2021

10.1016/S0065-3233(07)74004-4

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17854657