(Q36947039)

English

Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses.

scientific article published on 23 May 2016

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scholarly article

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2 April 2020

Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses (English)

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2 April 2020

vector-borne disease

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object named as

Vaccinia Virus

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based on heuristic

inferred from title

Juliana Falivene

2

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2 April 2020

María Fernanda Pascutti

5

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2 April 2020

Maria Belen Vecchione

6

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2 April 2020

Andrea Bruttomesso

7

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2 April 2020

María Paula Del Médico Zajac

9

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2 April 2020

author name string

María Pía Holgado

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2 April 2020

Cynthia Maeto

3

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2 April 2020

Micaela Amigo

4

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2 April 2020

Gabriela Calamante

8

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2 April 2020

María Magdalena Gherardi

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publication date

23 May 2016

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2 April 2020

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2 April 2020

8

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2 April 2020

5

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2 April 2020

copyright license

Creative Commons Attribution 4.0 International

23 May 2016

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April 2022 Public Data File from Crossref

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0 references

Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve Immunogenicity

1 reference

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29 September 2017

Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins

1 reference

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29 September 2017

Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles.

1 reference

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29 September 2017

Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.

1 reference

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29 September 2017

Novel mucosal DNA-MVA HIV vaccination in which DNA-IL-12 plus cholera toxin B subunit (CTB) cooperates to enhance cellular systemic and mucosal genital tract immunity

1 reference

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29 September 2017

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

1 reference

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29 September 2017

Deletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens.

1 reference

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29 September 2017

Clinical applications of attenuated MVA poxvirus strain.

1 reference

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29 September 2017

Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size.

1 reference

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29 September 2017

Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Clinical development of Modified Vaccinia virus Ankara vaccines

1 reference

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29 September 2017

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

IL-12 and GM-CSF in DNA/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and quality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

One-step simple assay to determine antigen-specific cytotoxic activities by single-color flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Regulation of effector and memory T-cell functions by type I interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

TroVax, a recombinant modified vaccinia Ankara virus encoding 5T4: lessons learned and future development

1 reference

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29 September 2017

MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults.

1 reference

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29 September 2017

Prime-boost vectored malaria vaccines: progress and prospects

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29 September 2017

Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Characterization of DNA and MVA vectors expressing Nef from HIV-1 CRF12_BF revealed high immune specificity with low cross-reactivity against subtype B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Innate immunity to virus infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Clinical development of MVA-based therapeutic cancer vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

CD8+ T cell efficacy in vaccination and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Antiviral innate immunity pathways.

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29 September 2017

Host-reactive CD8+ memory stem cells in graft-versus-host disease

1 reference

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29 September 2017

Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

1 reference

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29 September 2017

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

1 reference

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29 September 2017

Modified vaccinia Ankara: potential as an alternative smallpox vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

The biology of IL-12: coordinating innate and adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

The vaccinia virus superoxide dismutase-like protein (A45R) is a virion component that is nonessential for virus replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Effect of 3-beta-hydroxysteroid dehydrogenase gene deletion on virulence and immunogenicity of different vaccinia viruses and their recombinants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses

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29 September 2017

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

The envelope protein encoded by the A33R gene is required for formation of actin-containing microvilli and efficient cell-to-cell spread of vaccinia virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4885094

29 September 2017

Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates

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29 September 2017

Poxvirus vectors

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27 June 2018

Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara

1 reference

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27 June 2018

A constitutively expressed vaccinia gene encodes a 42-kDa glycoprotein related to complement control factors that forms part of the extracellular virus envelope

1 reference

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27 June 2018

Steroid hormone synthesis by a vaccinia enzyme: a new type of virus virulence factor.

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27 June 2018

Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

1 reference

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4 September 2018

Preparation of cell cultures and vaccinia virus stocks.

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4 September 2018

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

1 reference

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4 September 2018

Generation of CD8 T cell memory is regulated by IL-12.

1 reference

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4 September 2018

Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

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4 September 2018

Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes

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4 September 2018

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

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https://api.crossref.org/works/10.3390%2FV8050139

21 January 2018

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27223301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)

1 reference

https://pubmed.ncbi.nlm.nih.gov/27223301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/V8050139

1 reference

Europe PubMed Central

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2 April 2020

1 reference

Europe PubMed Central

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2 April 2020

1 reference

Europe PubMed Central

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2 April 2020

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