(Q36954095)

17 August 2017

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title

The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"? (English)

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17 August 2017

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Grace E Stutzmann

1

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17 August 2017

publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

13

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17 August 2017

issue

5

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17 August 2017

page(s)

546-559

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Tau in neurodegenerative diseases: tau phosphorylation and assembly

17 August 2017

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Calcium - a life and death signal

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

21 January 2018

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Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders

21 January 2018

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Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death

21 January 2018

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The effects of oxidative stress and altered intracellular calcium levels on vesicular transport of apoE-EGFP.

21 January 2018

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Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

21 January 2018

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

21 January 2018

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Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice

21 January 2018

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Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue

21 January 2018

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Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

21 January 2018

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

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Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide.

21 January 2018

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21 January 2018

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The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells

21 January 2018

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21 January 2018

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

21 January 2018

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Extracellular tau is toxic to neuronal cells.

21 January 2018

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Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels.

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

21 January 2018

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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Tau pathology in Alzheimer disease and other tauopathies

21 January 2018

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Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

21 January 2018

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Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis

21 January 2018

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Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

21 January 2018

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beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

21 January 2018

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Hypothesis on the regulation of cytosol calcium concentration and the aging brain

21 January 2018

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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

21 January 2018

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Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

21 January 2018

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Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

21 January 2018

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ER stress and neurodegenerative diseases

21 January 2018

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Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

21 January 2018

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Apoptosis in neurodegenerative disorders

21 January 2018

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beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

21 January 2018

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Neuronal and glial calcium signaling in Alzheimer's disease

21 January 2018

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Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

21 January 2018

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 January 2018

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Mechanisms of Ca(2+)-dependent transcription

21 January 2018

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Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide.

21 January 2018

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

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Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway

21 January 2018

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Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Roles of CHOP/GADD153 in endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

The ER-overload response: activation of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Aging and Alzheimer's disease: lessons from the Nun Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Monitoring of free calcium in the neuronal endoplasmic reticulum: an overview of modern approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Calcium dysregulation, IP3 signaling, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Hypoxic enhancement of quantal catecholamine secretion. Evidence for the involvement of amyloid beta-peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Neuronal ageing from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Ca2+ regulation and gene expression in normal brain aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Homer: a link between neural activity and glutamate receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Potentiation of inositol trisphosphate‐induced Ca2+ mobilization in Xenopus oocytes by cytosolic Ca2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407299730

21 January 2018

Identifiers

DOI

10.1177/1073858407299730

1 reference

17 August 2017

1 reference