(Q36970033)

English

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

scientific article published on 28 June 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

0 references

1 reference

based on heuristic

inferred from title

Benjamin Cravatt

4

object named as

Benjamin F Cravatt

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Jessica K DeMartino

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Joie Garfunkle

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dustin G Hochstatter

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dale L Boger

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

28 June 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Bioorganic & Medicinal Chemistry Letters

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

18

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

22

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

5842-5846

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase

1 reference

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Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.

1 reference

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Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality

1 reference

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29 September 2017

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

1 reference

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Halogen dance reactions--a review

1 reference

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29 September 2017

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

1 reference

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Attenuation of allergic contact dermatitis through the endocannabinoid system

1 reference

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29 September 2017

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase

1 reference

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29 September 2017

Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors

1 reference

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The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

1 reference

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

1 reference

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Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

1 reference

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Identification of a high-affinity binding site involved in the transport of endocannabinoids

1 reference

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Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

1 reference

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The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

1 reference

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29 September 2017

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

1 reference

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29 September 2017

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

1 reference

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29 September 2017

Functional disassociation of the central and peripheral fatty acid amide signaling systems

1 reference

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29 September 2017

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

1 reference

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29 September 2017

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

1 reference

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29 September 2017

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

1 reference

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29 September 2017

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

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Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

1 reference

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

1 reference

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Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides

1 reference

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Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

1 reference

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Activity-based protein profiling: the serine hydrolases

1 reference

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Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules

1 reference

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An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase

1 reference

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Molecular characterization of human and mouse fatty acid amide hydrolases

1 reference

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Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

1 reference

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

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Chemical characterization of a family of brain lipids that induce sleep

1 reference

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

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Clarifying the catalytic roles of conserved residues in the amidase signature family

1 reference

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Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

1 reference

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Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase

1 reference

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Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.

1 reference

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1 reference

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Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations

1 reference

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1 reference

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Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

1 reference

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Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase

1 reference

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Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

1 reference

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1 reference

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Profiling serine hydrolase activities in complex proteomes

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4 September 2018

Fatty acid amide hydrolase substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18639454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

1 reference

https://pubmed.ncbi.nlm.nih.gov/18639454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18639454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel inhibitors of fatty acid amide hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18639454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of arachidonoyl ethanolamide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18639454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMCL.2008.06.084

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

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