(Q36978952)

17 August 2017

1 reference

title

Cellular oxygen sensing in health and disease (English)

1 reference

17 August 2017

1 reference

David R Mole

1

0 references

Peter J. Ratcliffe

object named as

Peter J Ratcliffe

series ordinal

2

0 references

language of work or name

1 reference

23 October 2007

1 reference

17 August 2017

1 reference

17 August 2017

volume

23

1 reference

17 August 2017

issue

5

1 reference

17 August 2017

page(s)

681-694

1 reference

https://scigraph.springernature.com/pub.10.1007/s00467-007-0632-x

17 August 2017

exact match

0 references

cites work

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00467-007-0632-X

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00467-007-0632-X

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00467-007-0632-X

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

12 December 2020

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

1 reference

12 December 2020

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

12 December 2020

Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

1 reference

12 December 2020

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

1 reference

12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 December 2020

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

1 reference

12 December 2020

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

1 reference

12 December 2020

Role of fibroblast growth factor receptor signaling in kidney development

1 reference

12 December 2020

Expression of hypoxia-inducible transcription factors in developing human and rat kidneys.

1 reference

12 December 2020

Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.

1 reference

12 December 2020

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

1 reference

12 December 2020

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

1 reference

12 December 2020

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

12 December 2020

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

1 reference

12 December 2020

Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys

1 reference

12 December 2020

Activation of the HIF pathway in cancer

1 reference

12 December 2020

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

12 December 2020

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression

1 reference

12 December 2020

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1 reference

12 December 2020

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 December 2020

Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators

1 reference

12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 December 2020

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

1 reference

12 December 2020

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

1 reference

12 December 2020

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies.

1 reference

12 December 2020

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

1 reference

12 December 2020

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

12 December 2020

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 December 2020

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis

1 reference

12 December 2020

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

12 December 2020

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 December 2020

Erythropoietin: structure, control of production, and function

1 reference

12 December 2020

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

12 December 2020

Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development

1 reference

12 December 2020

The role of HIF-1alpha in myeloid cell inflammation

1 reference

12 December 2020

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

12 December 2020

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

12 December 2020

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene.

1 reference

12 December 2020

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha

1 reference

12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 December 2020

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

12 December 2020

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

1 reference

12 December 2020

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 December 2020

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

1 reference

12 December 2020

Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2

1 reference

12 December 2020

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

12 December 2020

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

1 reference

12 December 2020

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

12 December 2020

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 December 2020

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

12 December 2020

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 December 2020

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 December 2020

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

1 reference

12 December 2020

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives

1 reference

12 December 2020

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

1 reference

12 December 2020

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 December 2020

Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

1 reference

12 December 2020

Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

1 reference

12 December 2020

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

12 December 2020

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

1 reference

12 December 2020

Regulatory elements of the erythropoietin gene.

1 reference

12 December 2020

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 December 2020

Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia

1 reference

12 December 2020

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

12 December 2020

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

12 December 2020

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

12 December 2020

Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha

1 reference

12 December 2020

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

1 reference

12 December 2020

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

1 reference

12 December 2020

Hypoxia--a key regulatory factor in tumour growth

1 reference

12 December 2020

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis

1 reference

12 December 2020

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

12 December 2020

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 December 2020

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 December 2020

Oxygen sensing in the kidney and its relation to erythropoietin production

1 reference

12 December 2020

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

12 December 2020

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 December 2020

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 December 2020

Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration

1 reference

12 December 2020

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 December 2020

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 December 2020

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

12 December 2020

Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia

1 reference

12 December 2020

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 December 2020

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

1 reference

12 December 2020

Hypoxia-Inducible Factors and Kidney Vascular Development

1 reference

12 December 2020

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

12 December 2020

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

12 December 2020

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

12 December 2020

A role for mitochondrial enzymes in inherited neoplasia and beyond

1 reference

12 December 2020

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

1 reference

12 December 2020

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 December 2020

Oxygen sensing by HIF hydroxylases

1 reference

12 December 2020

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

1 reference

12 December 2020

Oxygen and iron regulation of iron regulatory protein 2.

1 reference

12 December 2020

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

12 December 2020

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

12 December 2020

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

1 reference

12 December 2020

Acute-on-chronic renal failure in the rat: functional compensation and hypoxia tolerance

1 reference

12 December 2020

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 December 2020

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

12 December 2020

The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

1 reference

12 December 2020

Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

1 reference

12 December 2020

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways

1 reference

12 December 2020

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

12 December 2020

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 December 2020

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 December 2020

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

12 December 2020

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

1 reference

12 December 2020

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

12 December 2020

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 December 2020

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

12 December 2020

The HIF pathway as a therapeutic target

1 reference

12 December 2020

10.1007/S00467-007-0632-X

Identifiers

DOI

1 reference

17 August 2017

1 reference