(Q36999054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

1 reference

title

Transgenic models to understand hypoxia-inducible factor function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Randall S. Johnson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

author name string

Andrew Doedens

series ordinal

1

1 reference

17 August 2017

Randall S Johnson

series ordinal

2

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

published in

Methods in Enzymology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

435

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

87-105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

Genetic evidence for a tumor suppressor role of HIF-2alpha.

10 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The hypoxic response of tumors is dependent on their microenvironment.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Mop3 is an essential component of the master circadian pacemaker in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The bHLH/PAS factor MOP3 does not participate in hypoxia responses

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

ARNT-deficient mice and placental differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Tissue- and site-specific DNA recombination in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Inducible gene targeting in mice using the Cre/lox system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

pVHL function is essential for endothelial extracellular matrix deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935005-2

7 January 2021

10.1016/S0076-6879(07)35005-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998050%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference