(Q37016007)

17 August 2017

1 reference

title

PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma (English)

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17 August 2017

2

Sagar Lonial

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17 August 2017

R Donald Harvey

1

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17 August 2017

language of work or name

English

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publication date

1 December 2007

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17 August 2017

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17 August 2017

volume

3

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17 August 2017

issue

6

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17 August 2017

page(s)

639-647

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17 August 2017

cites work

Cancer statistics, 2007

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

CD28-mediated regulation of multiple myeloma cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Activation of Akt predicts poor outcome in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The prognostic value of PTEN, p53, and beta-catenin in endometrial carcinoma: a prospective immunocytochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Analysis of PTEN deletions and mutations in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

PTEN: one gene, many syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

PTEN, more than the AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The Akt-mTOR tango and its relevance to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

PI3K/Akt and apoptosis: size matters

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

PI 3-kinase, Akt and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

FOXO1A Is a Candidate for the 13q14 Tumor Suppressor Gene Inhibiting Androgen Receptor Signaling in Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The significance of the Wnt pathway in the pathology of human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Interleukin-6 activates phosphoinositol-3' kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Downstream effectors of oncogenic ras in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Molecular pathogenesis and a consequent classification of multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Antimyeloma activity of heat shock protein-90 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.3.6.639

21 January 2018

Identifiers

DOI

10.2217/14796694.3.6.639

1 reference

release_2lq4vlimpbfbbeyjo5j4efcke4

17 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2lq4vlimpbfbbeyjo5j4efcke4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference