(Q37030872)

17 August 2017

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title

Targeting synuclein-gamma to counteract drug resistance in cancer (English)

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17 August 2017

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Vinay K Singh

1

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17 August 2017

Zongchao Jia

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 January 2008

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

12

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17 August 2017

issue

1

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17 August 2017

page(s)

59-68

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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

17 August 2017

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Tumor senescence as a determinant of drug response in vivo

21 January 2018

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Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions.

21 January 2018

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Drug resistance reversal--are we getting closer?

21 January 2018

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p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

21 January 2018

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Microtubules, microtubule-interfering agents and apoptosis.

21 January 2018

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AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2

21 January 2018

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The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

21 January 2018

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A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.

21 January 2018

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Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules

21 January 2018

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Modulation of paclitaxel resistance by annexin IV in human cancer cell lines

21 January 2018

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Chk1 is required for spindle checkpoint function.

21 January 2018

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Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer

21 January 2018

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Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux.

21 January 2018

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Drug resistance in chemotherapy for breast cancer

21 January 2018

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Genetic analysis of the multidrug transporter

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

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Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1

21 January 2018

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Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

21 January 2018

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21 January 2018

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Synucleins and their relationship to Parkinson's disease.

21 January 2018

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Neuropathology of synuclein aggregates

21 January 2018

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Identification, localization and characterization of the human gamma-synuclein gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M.

21 January 2018

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Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells

21 January 2018

1 reference

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Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

21 January 2018

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Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas

21 January 2018

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Gamma-synuclein and the progression of cancer

21 January 2018

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Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.

21 January 2018

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Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Microtubules as a target for anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action

21 January 2018

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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

The spindle-assembly checkpoint in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30.

21 January 2018

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Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Estrogen receptor expression and sensitivity to paclitaxel in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Drugs targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Natively unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

The Key–Lock Theory and the Induced Fit Theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Tatp-mediated intracellular delivery of pharmaceutical nanocarriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Carrier-mediated delivery of peptidic drugs for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Liposomalized oligopeptides in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Anti-cancer activity of targeted pro-apoptotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

Chromosomal instability, colorectal cancer and taxane resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.59

21 January 2018

Identifiers

DOI

10.1517/14728222.12.1.59

1 reference

17 August 2017

1 reference