(Q37057272)

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Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules

scientific article published on July 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

18 August 2017

Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Alzheimer's disease

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Nikolai Petrovsky

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Nikolai Petrovsky

9

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author name string

Hayk Davtyan

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Karen Zagorski

2

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Europe PubMed Central

PMC publication ID

18 August 2017

Harinda Rajapaksha

3

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Europe PubMed Central

PMC publication ID

18 August 2017

Armine Hovakimyan

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Arpine Davtyan

5

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Europe PubMed Central

PMC publication ID

18 August 2017

Irina Petrushina

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Konstantin Kazarian

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

David H Cribbs

8

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Europe PubMed Central

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18 August 2017

Michael G Agadjanyan

10

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Europe PubMed Central

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18 August 2017

Anahit Ghochikyan

11

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18 August 2017

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publication date

1 July 2016

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Europe PubMed Central

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18 August 2017

Scientific Reports

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18 August 2017

6

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Europe PubMed Central

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18 August 2017

28912

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Europe PubMed Central

PMC publication ID

18 August 2017

copyright license

Creative Commons Attribution 4.0 International

1 July 2016

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April 2022 Public Data File from Crossref

copyright status

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https://scigraph.springernature.com/pub.10.1038/srep28912

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Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

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A fresh perspective from immunologists and vaccine researchers: active vaccination strategies to prevent and reverse Alzheimer's disease

1 reference

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Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine

1 reference

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Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

1 reference

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Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

1 reference

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New developments of clinical trial in immunotherapy for Alzheimer's disease

1 reference

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Tau immunotherapy for Alzheimer's disease

1 reference

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Anti-tau antibody reduces insoluble tau and decreases brain atrophy

1 reference

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Immunotherapeutic approaches for Alzheimer's disease

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Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology

1 reference

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Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Immunogenicity of DNA- and recombinant protein-based Alzheimer disease epitope vaccines

1 reference

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29 September 2017

Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis

1 reference

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29 September 2017

Open questions for Alzheimer's disease immunotherapy

1 reference

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29 September 2017

Tau immunotherapy and imaging.

1 reference

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29 September 2017

Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques

1 reference

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29 September 2017

An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody

1 reference

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29 September 2017

Understanding immunosenescence to improve responses to vaccines

1 reference

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29 September 2017

"Prion-like" templated misfolding in tauopathies

1 reference

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29 September 2017

Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

1 reference

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29 September 2017

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Tau oligomers and tau toxicity in neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4929459

29 September 2017

Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant

1 reference

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Targeting Beta amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease

1 reference

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'Clinical trials in Alzheimer's disease': immunotherapy approaches

1 reference

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Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

1 reference

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Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets

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Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.

1 reference

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SDS-PAGE/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrieval

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Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

1 reference

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Prion-like mechanisms in neurodegenerative diseases

1 reference

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DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice.

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Axonal transport defects in neurodegenerative diseases

1 reference

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Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

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Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy

1 reference

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Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice

1 reference

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1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

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Immunology and immunotherapy of Alzheimer's disease

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Current progress in beta-amyloid immunotherapy

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Formation and propagation of tau oligomeric seeds

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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

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Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

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4 September 2018

Identifiers

10.1038/SREP28912

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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