(Q38099071)

28 August 2017

title

"Prion-like" templated misfolding in tauopathies (English)

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28 August 2017

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6

Markus Tolnay

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author name string

Florence Clavaguera

1

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28 August 2017

Isabelle Lavenir

2

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28 August 2017

Ben Falcon

3

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28 August 2017

Stephan Frank

4

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28 August 2017

Michel Goedert

5

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28 August 2017

Markus Tolnay

6

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28 August 2017

publication date

1 May 2013

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28 August 2017

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28 August 2017

volume

23

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28 August 2017

issue

3

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28 August 2017

page(s)

342-349

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Inhibition of tau filament formation by conformational modulation.

28 August 2017

cites work

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Structure and novel exons of the human tau gene

21 January 2018

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Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

21 January 2018

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

21 January 2018

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Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

21 January 2018

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Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

21 January 2018

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The distribution of tau in the mammalian central nervous system

21 January 2018

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Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

21 January 2018

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Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease

21 January 2018

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

21 January 2018

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Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

21 January 2018

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

21 January 2018

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Tau protein and tau aggregation inhibitors

21 January 2018

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Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

21 January 2018

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Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

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Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

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Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

21 January 2018

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Abnormal tau-containing filaments in neurodegenerative diseases

21 January 2018

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β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

21 January 2018

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Proteasomal degradation of tau protein

21 January 2018

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Propagation of tau pathology in a model of early Alzheimer's disease

21 January 2018

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Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

21 January 2018

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The amyloid state of proteins in human diseases

21 January 2018

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Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly

21 January 2018

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Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy.

21 January 2018

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Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type.

21 January 2018

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Propagation of tau misfolding from the outside to the inside of a cell.

21 January 2018

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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

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The propagation of prion-like protein inclusions in neurodegenerative diseases

21 January 2018

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p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

21 January 2018

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

21 January 2018

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

21 January 2018

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Extracellular tau is toxic to neuronal cells.

21 January 2018

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Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

21 January 2018

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

21 January 2018

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Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

21 January 2018

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Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

21 January 2018

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

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Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies

21 January 2018

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Trans-cellular propagation of Tau aggregation by fibrillar species

21 January 2018

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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

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Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy.

21 January 2018

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The carboxyl third of tau is tightly bound to paired helical filaments.

21 January 2018

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

21 January 2018

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An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

21 January 2018

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Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

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Trans-synaptic spread of tau pathology in vivo

21 January 2018

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

21 January 2018

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

21 January 2018

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Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

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Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy

21 January 2018

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

Quantitative analysis of neurofibrillary pathology in a general population to reappraise neuropathological criteria for senile dementia of the neurofibrillary tangle type (tangle-only dementia): the Hisayama Study

21 January 2018

1 reference

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

21 January 2018

1 reference

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

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Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment.

21 January 2018

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Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.

21 January 2018

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

21 January 2018

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Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes

21 January 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

21 January 2018

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Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

21 January 2018

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Advanced Maillard reaction end products are associated with Alzheimer disease pathology

21 January 2018

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

21 January 2018

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Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation

21 January 2018

1 reference

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments

21 January 2018

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

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Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

21 January 2018

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Argyrophilic grain disease is a sporadic 4-repeat tauopathy

21 January 2018

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Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies

21 January 2018

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Frontotemporal lobar degeneration--tau as a pied piper?

21 January 2018

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Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

21 January 2018

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Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

21 January 2018

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Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease.

21 January 2018

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A protein factor essential for microtubule assembly

21 January 2018

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Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy.

21 January 2018

1 reference

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

21 January 2018

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Structural characterization of the core of the paired helical filament of Alzheimer disease

21 January 2018

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

21 January 2018

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

21 January 2018

1 reference

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

21 January 2018

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In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

21 January 2018

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Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue

21 January 2018

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BPA.12044

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28 August 2017

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