(Q37078850)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

0 references

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Laura Martínez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

José C Fernández-Checa

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Anna Colell

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Elisabet Barbero-Camps

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

publication date

6 May 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

3460-3476

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

29 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3736868/fullTextXML

inferred from PubMed Central ID database lookup

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29 September 2017

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29 September 2017

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Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

29 September 2017

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The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.

29 September 2017

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Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies

29 September 2017

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29 September 2017

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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

29 September 2017

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Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet

29 September 2017

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Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains

29 September 2017

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Probing the biology of Alzheimer's disease in mice

29 September 2017

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

29 September 2017

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Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease.

29 September 2017

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Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry

29 September 2017

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Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression

29 September 2017

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Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

29 September 2017

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Mitochondrial glutathione, a key survival antioxidant

29 September 2017

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Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.

29 September 2017

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Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity

29 September 2017

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Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

29 September 2017

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Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

29 September 2017

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Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

29 September 2017

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Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts.

29 September 2017

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Mitochondrial cholesterol in health and disease

29 September 2017

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Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease

29 September 2017

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

29 September 2017

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Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production

29 September 2017

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Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

29 September 2017

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Alzheimer disease models and human neuropathology: similarities and differences

29 September 2017

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

29 September 2017

1 reference

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ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

29 September 2017

1 reference

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Mitochondrial oxidative stress causes hyperphosphorylation of tau.

29 September 2017

1 reference

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Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

29 September 2017

1 reference

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Mice as models: transgenic approaches and Alzheimer's disease.

29 September 2017

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

29 September 2017

1 reference

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Cholesterol homeostasis and function in neurons of the central nervous system

29 September 2017

1 reference

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

29 September 2017

1 reference

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The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

29 September 2017

1 reference

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Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

29 September 2017

1 reference

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Recognition memory: what are the roles of the perirhinal cortex and hippocampus?

29 September 2017

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Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

29 September 2017

1 reference

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Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

29 September 2017

1 reference

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Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

29 September 2017

1 reference

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Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain.

29 September 2017

1 reference

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Developments of a water-maze procedure for studying spatial learning in the rat

29 September 2017

1 reference

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

29 September 2017

1 reference

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Neuropathological stageing of Alzheimer-related changes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Direct and potent regulation of gamma-secretase by its lipid microenvironment

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Cholesterol storage and tau pathology in Niemann–Pick type C disease in the brain

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736868

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

4 September 2018

1 reference

12 December 2020

Determination of free, total, and esterified cholesterol by high-performance liquid chromatography

1 reference

12 December 2020

Neurofibrillary tangles in Niemann-Pick disease type C

1 reference

12 December 2020

Pitavastatin decreases tau levels via the inactivation of Rho/ROCK

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDT201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

23648430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23648430%20AND%20SRC:MED&resulttype=core&format=json