(Q39293578)

English

Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway

scientific article published on 21 August 2012

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scholarly article

1 reference

Europe PubMed Central

10 September 2017

Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway (English)

1 reference

Europe PubMed Central

10 September 2017

1 reference

based on heuristic

inferred from title

author name string

Takayoshi Tokutake

1

1 reference

Europe PubMed Central

10 September 2017

Kensaku Kasuga

2

1 reference

Europe PubMed Central

10 September 2017

Ryuji Yajima

3

1 reference

Europe PubMed Central

10 September 2017

Yumi Sekine

4

1 reference

Europe PubMed Central

10 September 2017

Toshiyuki Tezuka

5

1 reference

Europe PubMed Central

10 September 2017

Masatoyo Nishizawa

6

1 reference

Europe PubMed Central

10 September 2017

Takeshi Ikeuchi

7

1 reference

Europe PubMed Central

10 September 2017

language of work or name

0 references

publication date

21 August 2012

1 reference

Europe PubMed Central

10 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

10 September 2017

287

1 reference

Europe PubMed Central

10 September 2017

42

1 reference

Europe PubMed Central

10 September 2017

35222-35233

1 reference

Europe PubMed Central

10 September 2017

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

1 reference

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10 September 2017

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

1 reference

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10 September 2017

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

1 reference

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10 September 2017

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

1 reference

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10 September 2017

Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential

1 reference

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10 September 2017

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study

1 reference

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10 September 2017

Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study

1 reference

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

1 reference

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10 September 2017

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

1 reference

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10 September 2017

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

1 reference

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10 September 2017

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

1 reference

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10 September 2017

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

1 reference

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10 September 2017

Amyloid beta-protein assembly and Alzheimer disease

1 reference

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10 September 2017

Structural classification of toxic amyloid oligomers

1 reference

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10 September 2017

The GSK3 hypothesis of Alzheimer's disease

1 reference

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10 September 2017

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

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10 September 2017

Risk of dementia in diabetes mellitus: a systematic review

1 reference

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10 September 2017

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Post-translational modifications of tau protein in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

10 September 2017

Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

1 reference

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14 September 2017

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

14 September 2017

Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

14 September 2017

Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

17 June 2018

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

17 June 2018

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

17 June 2018

Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

17 June 2018

Glucose tolerance status and risk of dementia in the community: the Hisayama study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

21 August 2018

Microdialysis combined blood sampling technique for the determination of rosiglitazone and glucose in brain and blood of gerbils subjected to cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

21 August 2018

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

21 August 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

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21 August 2018

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

1 reference

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21 August 2018

Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.

1 reference

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21 August 2018

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

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21 August 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

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21 August 2018

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

1 reference

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21 August 2018

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

1 reference

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21 August 2018

Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471719

21 August 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.348300

21 January 2018

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910909

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910909

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910909

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.348300

1 reference

Europe PubMed Central

10 September 2017

1 reference

Europe PubMed Central

10 September 2017

1 reference

Europe PubMed Central

10 September 2017

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