(Q40043261)

English

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease

scientific article published on November 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 September 2017

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Alzheimer's disease

0 references

phosphorylation

0 references

1 reference

based on heuristic

inferred from title

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Akiyoshi Kakita

2

object named as

Akiyoshi Kakita

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

author name string

Hiroyuki Kaneko

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Hiroaki Nozaki

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Atsushi Ishikawa

5

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Akinori Miyashita

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Ryozo Kuwano

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Takeshi Iwatsubo

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Hitoshi Takahashi

10

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Masatoyo Nishizawa

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Sangram S Sisodia

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Takeshi Ikeuchi

14

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

language of work or name

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publication date

1 November 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Journal of Neuroscience

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

27

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

48

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

13092-13097

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein forms a complex with transcription factor Elk-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New presenilin 1 mutation with Alzheimer disease and Lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta40 inhibits amyloid deposition in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18045903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4244-07.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673391&resulttype=core&format=json

16 May 2020

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