(Q37093674)

18 August 2017

1 reference

title

Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells (English)

1 reference

18 August 2017

1 reference

1 reference

Alan Kambiz Fotoohi

1

1 reference

PubMed ID

18297517

18 August 2017

Freidoun Albertioni

series ordinal

2

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18 August 2017

1 March 2008

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18 August 2017

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18 August 2017

49

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18 August 2017

3

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18 August 2017

410-426

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THE CONCENTRATION OF “FOLIC ACID”

18 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

SYNTHESIS OF A COMPOUND IDENTICAL WITH THE L. CASEI FACTOR ISOLATED FROM LIVER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

No Increase in Second Tumors after Cytotoxic Chemotherapy for Gestational Trophoblastic Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Presence of 2,4-diamino-N10-methylpteroic acid after high-dose methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Pharmacokinetic monitoring of high-dose methotrexate. Early recognition of high-risk patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Methotrexate hepatotoxicity in children with leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Evaluation of overall toxicity of high-dosage methotrexate regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Cloning of the human thiamine transporter, a member of the folate transporter family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

SLC19A3 encodes a second thiamine transporter ThTr2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

The cellular pharmacology of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Edatrexate, an antifolate with antitumor activity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

MRP3, an organic anion transporter able to transport anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Lack of an effect of breast cancer resistance protein (BCRP/ABCG2) overexpression on methotrexate polyglutamate export and folate accumulation in a human breast cancer cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Enzymatic synthesis and function of folylpolyglutamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Additional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Folate supplementation and methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Folate status and the safety profile of antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

The pharmacology and clinical use of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Resistance to methotrexate due to gene amplification in a patient with acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Gene amplification in a leukemic patient treated with methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Phenotypic Expression in Escherichia coli and Nucleotide Sequence of Two Chinese Hamster Lung Cell cDNAs Encoding Different Dihydrofolate Reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Pharmacogenetics of outcome in children with acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Resistance of the rabbit to methotrexate: Isolation of a drug metabolite with decreased cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

Drug dosage and remission duration in childhood lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190701824569

10.1080/10428190701824569

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18297517