(Q37098652)

English

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

scientific article published on 29 May 2008

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8 January 2020

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates (English)

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8 January 2020

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quantitative structure-activity relationship

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8 January 2020

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8 January 2020

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8 January 2020

Federica Vacondio

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8 January 2020

Giovanni Piersanti

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8 January 2020

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Andrea Duranti

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8 January 2020

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Andrea Tontini

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8 January 2020

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Giorgio Tarzia

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8 January 2020

Jason R Clapper

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Jason R Clapper

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8 January 2020

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Silvano Sanchini

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8 January 2020

Alvin R King

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8 January 2020

Daniele Piomelli

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8 January 2020

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29 May 2008

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8 January 2020

Journal of Medicinal Chemistry

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8 January 2020

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8 January 2020

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8 January 2020

3487-3498

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8 January 2020

URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Fatty acid amide hydrolase: from characterization to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

1 reference

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14 September 2017

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Structure and function of fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

The molecular logic of endocannabinoid signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

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14 September 2017

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

1 reference

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14 September 2017

The palmitoylethanolamide family: a new class of anti-inflammatory agents?

1 reference

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14 September 2017

The linear interaction energy method for predicting ligand binding free energies

1 reference

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14 September 2017

An anorexic lipid mediator regulated by feeding.

1 reference

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14 September 2017

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Control of pain initiation by endogenous cannabinoids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

14 September 2017

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

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14 September 2017

New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain

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29 September 2017

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

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27 June 2018

Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase

1 reference

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27 June 2018

The reaction of beta-cyclohexanedione (dihydroresorcinol) and its ethyl enol ether with phenylmagnesium bromide.

1 reference

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3 September 2018

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

1 reference

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3 September 2018

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.

1 reference

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3 September 2018

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

3 September 2018

Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

3 September 2018

The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3744893

3 September 2018

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

1 reference

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3 September 2018

QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.

1 reference

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3 September 2018

Substitution of hydroxybiaryls via directed ortho-lithiation of N-silylated O-aryl N-isopropylcarbamates

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3 September 2018

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3 September 2018

Calculation of the Binding Affinity of β-Secretase Inhibitors Using the Linear Interaction Energy Method

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3 September 2018

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4 December 2018

Are Automated Molecular Dynamics Simulations and Binding Free Energy Calculations Realistic Tools in Lead Optimization? An Evaluation of the Linear Interaction Energy (LIE) Method

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4 December 2018

Binding affinities for sulfonamide inhibitors with human thrombin using Monte Carlo simulations with a linear response method

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18507372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new method for predicting binding affinity in computer-aided drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/18507372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

1 reference

https://pubmed.ncbi.nlm.nih.gov/18507372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel inhibitors of fatty acid amide hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18507372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18507372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM701631Z

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18507372%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18507372%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18507372%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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