(Q37166339)

English

Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element

scientific article published on 17 March 2009

Physiological and Pathological Role of Alpha-synuclein in Parkinson’s Disease Through Iron Mediated Oxidative Stress; The Role of a Putative Iron-responsive Element

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26 January 2020

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20 September 2020

3 May 2021

8 October 2022

Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element (English)

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26 January 2020

Parkinson's disease

5 references

25 April 2019

4 November 2019

12 November 2019

19 December 2019

20 December 2019

inorganic compound

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4 November 2019

organometallic compound

1 reference

12 November 2019

nerve tissue protein

1 reference

19 December 2019

Parkinson disease associated proteins

1 reference

20 December 2019

1 reference

based on heuristic

inferred from title

oxidative stress

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ferric compounds

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3 May 2021

3

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26 January 2020

5

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26 January 2020

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David Olivares

1

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26 January 2020

Xudong Huang

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26 January 2020

Nigel H Greig

4

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1 March 2009

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3 May 2021

8 October 2022

International Journal of Molecular Sciences

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25 April 2019

4 November 2019

12 November 2019

19 December 2019

20 December 2019

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26 January 2020

1226-1260

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26 January 2020

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4 November 2019

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GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein

1 reference

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Parkinson's disease: genetics and beyond

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Different modes and potencies of translational repression by sequence-specific RNA-protein interaction at the 5'-UTR.

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

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Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

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Diagnosis and treatment of Parkinson disease: molecules to medicine

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6 September 2017

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

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Alpha-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy

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6 September 2017

Metal ions and oxidative protein modification in neurological disease.

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6 September 2017

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation

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Nosology of Parkinson's disease: looking for the way out of a quagmire

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Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

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6 September 2017

The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy?

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6 September 2017

Pathogenic effects of alpha-synuclein aggregation.

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6 September 2017

The role of alpha-synuclein in neurodegenerative diseases

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6 September 2017

alpha-Synuclein filaments bind the transcriptional regulator HMGB-1

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6 September 2017

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies

1 reference

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6 September 2017

Synucleins and their relationship to Parkinson's disease.

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6 September 2017

Does cellular iron dysregulation play a causative role in Parkinson's disease?

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6 September 2017

alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease

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6 September 2017

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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6 September 2017

alpha-Synuclein locus triplication causes Parkinson's disease

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Drug Discovery Targeted to the Alzheimer's APP mRNA 5'-Untranslated Region: The Action of Paroxetine and Dimercaptopropanol

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6 September 2017

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

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6 September 2017

What have we learnt from CDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease?

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6 September 2017

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

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6 September 2017

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

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6 September 2017

The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects

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6 September 2017

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

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Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

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Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment

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Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies

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Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

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6 September 2017

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

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Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

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Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation

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6 September 2017

Tubulin seeds alpha-synuclein fibril formation

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6 September 2017

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6 September 2017

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6 September 2017

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

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6 September 2017

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Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells

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6 September 2017

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6 September 2017

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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6 September 2017

Synucleins in synaptic plasticity and neurodegenerative disorders

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6 September 2017

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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6 September 2017

Folding intermediates of SNARE complex assembly

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6 September 2017

The synuclein family

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6 September 2017

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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6 September 2017

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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6 September 2017

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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6 September 2017

Is levodopa toxic to human substantia nigra?

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6 September 2017

Alpha-synuclein in Lewy bodies

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6 September 2017

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network

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6 September 2017

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

PEST sequences and regulation by proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Iron in brain function and dysfunction with emphasis on Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

Ferritin: a cytoprotective antioxidant strategem of endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

6 September 2017

The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

14 September 2017

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

28 September 2017

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

28 September 2017

alpha-Synuclein forms a complex with transcription factor Elk-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

28 September 2017

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

28 September 2017

Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

28 September 2017

Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Neuroferritinopathy: a window on the role of iron in neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Poly(A)-tail-promoted translation in yeast: implications for translational control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Synthetic filaments assembled from C-terminally truncated alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

The ubiquitin pathway in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Autosomal dominant Parkinson's disease and alpha-synuclein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

27 June 2018

Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Forcing nonamyloidogenic beta-synuclein to fibrillate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Iron dysregulation and Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Accumulation of phosphorylated alpha-synuclein in aging human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Structural and functional implications of C-terminal regions of alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

[Inhibition of catechol-O-methyltransferase. Optimizing dopaminergic therapy in idiopathic Parkinson syndrome with entacapone].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Clinical and quantitative pathologic correlates of dementia with Lewy bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Apomorphine protects against MPTP-induced neurotoxicity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

Phosphorylation of a vesicular monoamine transporter by casein kinase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672027

3 September 2018

-Synuclein and Parkinson disease susceptibility

1 reference

https://api.crossref.org/works/10.3390%2FIJMS10031226

21 January 2018

Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequestration of iron by Lewy bodies in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-Lactalbumin: compact state with fluctuating tertiary structure?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of pergolide and MDL 72974 on rat brain CuZn superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein membrane interactions and lipid specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association study between iron-related genes polymorphisms and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Long-term therapy of the Parkinson syndrome]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early combination therapy (bromocriptine and levodopa) does not prevent motor fluctuations in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinsonism in Ontario: increased mortality compared with controls in a large cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The early treatment of Parkinson's disease: levodopa, dopamine agonists or both

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19399246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS10031226

1 reference

https://api.fatcat.wiki/v0/release/i7iy5w24qjfb3aa7dcptczol5e

30 July 2022

based on heuristic

mapped directly with Wikidata item

release_i7iy5w24qjfb3aa7dcptczol5e

1 reference

https://api.fatcat.wiki/v0/release/i7iy5w24qjfb3aa7dcptczol5e

30 July 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

https://api.fatcat.wiki/v0/release/i7iy5w24qjfb3aa7dcptczol5e

30 July 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

https://api.fatcat.wiki/v0/release/i7iy5w24qjfb3aa7dcptczol5e

30 July 2022

based on heuristic

mapped directly with Wikidata item

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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Wikiquote(0 entries)

Wikisource(0 entries)

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