(Q37178335)

English

Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

scientific article published on 16 August 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

based on heuristic

inferred from title

evasion of host immune response

1 reference

based on heuristic

inferred from title

Michel Mittelbronn

9

object named as

Michel Mittelbronn

1 reference

Europe PubMed Central

18 August 2017

PMC publication ID

Jörg Wischhusen

10

object named as

Jörg Wischhusen

1 reference

Europe PubMed Central

18 August 2017

PMC publication ID

author name string

Itsaso Montalbán Del Barrio

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cornelia Penski

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Laura Schlahsa

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Roland G Stein

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Joachim Diessner

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Achim Wöckel

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Johannes Dietl

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Manfred B Lutz

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Sebastian F M Häusler

11

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

16 August 2016

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal for Immunotherapy of Cancer

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

49

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

https://scigraph.springernature.com/pub.10.1186/s40425-016-0154-9

0 references

Purinergic Signaling During Immune Cell Trafficking.

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CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

1 reference

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6 September 2017

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

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6 September 2017

Regulation of tumor metastasis by myeloid-derived suppressor cells

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6 September 2017

History of myeloid-derived suppressor cells

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6 September 2017

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse

1 reference

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6 September 2017

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

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6 September 2017

Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer

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6 September 2017

Adenosine signaling during acute and chronic disease states

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6 September 2017

Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states

1 reference

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6 September 2017

Immunogenic cell death and DAMPs in cancer therapy

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6 September 2017

Anti-tumour strategies aiming to target tumour-associated macrophages.

1 reference

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6 September 2017

Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma

1 reference

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6 September 2017

CD73: a potent suppressor of antitumor immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

CD73-deficient mice are resistant to carcinogenesis

1 reference

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6 September 2017

Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Prognostic and predictive impact of intra- and peritumoral immune infiltrates

1 reference

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6 September 2017

Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Peritoneal immune system in patients with advance epithelial ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Macrophage diversity enhances tumor progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Myeloid-derived suppressor cell heterogeneity and subset definition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine in fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Deletion of cd39/entpd1 results in hepatic insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Altered macrophage differentiation and immune dysfunction in tumor development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

A2A adenosine receptor protects tumors from antitumor T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

P2X receptors as cell-surface ATP sensors in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

GRO family chemokines are specialized for monocyte arrest from flow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Tumour-educated macrophages promote tumour progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine: an endogenous regulator of innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Ecto-enzyme and signaling functions of lymphocyte CD73

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

Adenosine promotes neutrophil chemotaxis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

6 September 2017

A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

14 September 2017

Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

14 September 2017

Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

27 June 2018

Regulatory T Cells from Colon Cancer Patients Inhibit Effector T-cell Migration through an Adenosine-Dependent Mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and interactions with monocytes during atherosclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

CD73 expression as a potential marker of good prognosis in breast carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

"Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Adenosine slows migration of dendritic cells but does not affect other aspects of dendritic cell maturation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Disordered cellular migration and angiogenesis in cd39-null mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986205

3 September 2018

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

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21 January 2018

The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27532024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27

1 reference

https://pubmed.ncbi.nlm.nih.gov/27532024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27532024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/27532024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S40425-016-0154-9

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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