(Q37211962)

English

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

scientific article published on 12 September 2013

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scholarly article

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PMC publication ID

19 August 2017

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma (English)

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PMC publication ID

19 August 2017

4

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13 June 2020

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13 June 2020

Ricky W Johnstone

12

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13 June 2020

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G M Matthews

1

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13 June 2020

M Lefebure

2

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13 June 2020

M A Doyle

3

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13 June 2020

M Chesi

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13 June 2020

K M Banks

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13 June 2020

E Vidacs

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13 June 2020

D Faulkner

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13 June 2020

P Atadja

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13 June 2020

P L Bergsagel

11

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13 June 2020

publication date

12 September 2013

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19 August 2017

Cell Death and Disease

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13 June 2020

4

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13 June 2020

e798

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13 June 2020

describes a project that uses

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22 June 2022

https://europepmc.org/article/PMC/3789166

based on heuristic

inferred from PubMed Central ID database lookup

Camera: a competitive gene set test accounting for inter-gene correlation

1 reference

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14 September 2017

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

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14 September 2017

Management of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).

1 reference

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14 September 2017

Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

1 reference

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Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.

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HDAC inhibitors and cancer therapy.

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14 September 2017

c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

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Drug combination studies and their synergy quantification using the Chou-Talalay method

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14 September 2017

The potential role of epigenetic therapy in multiple myeloma

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14 September 2017

Cancer stem cells: controversies in multiple myeloma

1 reference

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14 September 2017

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

1 reference

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14 September 2017

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

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14 September 2017

Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges

1 reference

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14 September 2017

HDACi--targets beyond chromatin.

1 reference

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14 September 2017

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

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BCL-2 family antagonists for cancer therapy

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14 September 2017

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

1 reference

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The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

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14 September 2017

The TRAIL apoptotic pathway in cancer onset, progression and therapy

1 reference

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14 September 2017

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

14 September 2017

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

14 September 2017

Bortezomib: a novel chemotherapeutic agent for hematologic malignancies

1 reference

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14 September 2017

Histone deacetylase inhibitors in lymphoma and solid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

14 September 2017

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

1 reference

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Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications

1 reference

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14 September 2017

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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Anticancer activities of histone deacetylase inhibitors

1 reference

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14 September 2017

BCL-2: found bound and drugged!

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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14 September 2017

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

1 reference

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Multiple myeloma.

1 reference

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14 September 2017

Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

1 reference

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

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Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma.

1 reference

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14 September 2017

Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma

1 reference

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The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma

1 reference

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Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP.

1 reference

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The histone deacetylase inhibitor, PXD101, potentiates bortezomib-induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage

1 reference

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14 September 2017

Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL.

1 reference

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

1 reference

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The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

1 reference

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1 reference

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26 June 2018

Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

3 September 2018

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

3 September 2018

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

1 reference

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3 September 2018

AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

3 September 2018

Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

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Molecular sequelae of histone deacetylase inhibition in human malignant B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789166

3 September 2018

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2013.306

21 January 2018

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10.1038/CDDIS.2013.306

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24030150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24030150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24030150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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