(Q37235217)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Trisomy 21 consistently activates the interferon response (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Joseph M Cabral

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Matthew D Galbraith

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

James Degregori

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Joaquín M Espinosa

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

4

Ahwan Pandey

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Hannah C Lewis

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Amanda A Hill

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Leisa P Jackson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Keith P Smith

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

L Alexander Liggett

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Eliana B Gomez

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

language of work or name

English

0 references

publication date

29 July 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

20 March 2020

ImageQuant

object named as

ImageQuant

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5012864/fullTextXML

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

DESeq2

object named as

DESeq2

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

6 September 2017

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Ruxolitinib: a review of its use in patients with myelofibrosis

6 September 2017

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

6 September 2017

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Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate

6 September 2017

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Solid malignancies in individuals with Down syndrome: a case presentation and literature review

6 September 2017

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HTSeq--a Python framework to work with high-throughput sequencing data

6 September 2017

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Haematopoietic development and leukaemia in Down syndrome

6 September 2017

1 reference

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Validation of a blood protein signature for non-small cell lung cancer

6 September 2017

1 reference

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Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

6 September 2017

1 reference

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The scanning mechanism of eukaryotic translation initiation

6 September 2017

1 reference

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Causal analysis approaches in Ingenuity Pathway Analysis

6 September 2017

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The Akt-mTOR pathway in Down's syndrome: the potential use of rapamycin/rapalogs for treating cognitive deficits

6 September 2017

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6 September 2017

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Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

6 September 2017

1 reference

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Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes

6 September 2017

1 reference

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HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

6 September 2017

1 reference

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WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

6 September 2017

1 reference

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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

6 September 2017

1 reference

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AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL.

6 September 2017

1 reference

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Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

6 September 2017

1 reference

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Tinkering with translation: protein synthesis in virus-infected cells

6 September 2017

1 reference

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RSeQC: quality control of RNA-seq experiments

6 September 2017

1 reference

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ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

6 September 2017

1 reference

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Suppression of ribosomal protein synthesis and protein translation factors by Peg-interferon alpha/ribavirin in HCV patients blood mononuclear cells (PBMC).

6 September 2017

1 reference

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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

6 September 2017

1 reference

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Advances in human proteomics at high scale with the SOMAscan proteomics platform

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

A diverse range of gene products are effectors of the type I interferon antiviral response

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Pathway Commons, a web resource for biological pathway data

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Immunopathology of the human pancreas in type-I diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Dissecting interferon-induced transcriptional programs in human peripheral blood cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

MYC as a regulator of ribosome biogenesis and protein synthesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

CDK8 is a positive regulator of transcriptional elongation within the serum response network

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

The Sequence Alignment/Map format and SAMtools

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

WebGestalt: an integrated system for exploring gene sets in various biological contexts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Interferons and cerebral palsy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Presence of human chromosome 21 alone is sufficient for hybrid cell sensitivity to human interferon

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Inhibition of protein synthesis in noninfected L cells by partially purified interferon preparations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Low risk of solid tumors in persons with Down syndrome

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Morbidity and medication in a large population of individuals with Down syndrome compared to the general population

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Activity of the Janus kinase inhibitor ruxolitinib in chronic lymphocytic leukemia: results of a phase II trial

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

AnaLysis of Expression on human chromosome 21, ALE-HSA21: a pilot integrated web resource

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

A direct cross-talk between interferon-gamma and sonic hedgehog signaling that leads to the proliferation of neuronal precursor cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Anti-interferon immunoglobulins can improve the trisomy 16 mouse phenotype.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Interferon-mediated effect on ribosomal RNA metabolism

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

mTOR Hyperactivation in down syndrome hippocampus appears early during development.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Domains of genome-wide gene expression dysregulation in Down's syndrome.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Effects of small interfering RNAs targeting MAPK1 on gene expression profile in HeLa cells as revealed by microarray analysis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Interferon alpha-2a therapy in haemangiomas of infancy: spastic diplegia as a severe complication.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5012864

Long-term outcome of treatment with ruxolitinib in myelofibrosis

3 September 2018

1 reference

12 December 2020

Proceedings: The genetics of the antiviral state in human cells

1 reference

12 December 2020

Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state

1 reference

12 December 2020

Detection of mycoplasma in leukemia-lymphoma cell lines using polymerase chain reaction

1 reference

12 December 2020

Partial IFN-alpha/beta and IFN-gamma receptor knockout trisomy 16 mouse fetuses show improved growth and cultured neuron viability

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.16220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472900%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

27472900

1 reference