(Q39337933)

11 September 2017

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. (English)

1 reference

11 September 2017

10

Joaquín M Espinosa

1 reference

11 September 2017

Kelly D Sullivan

1

1 reference

11 September 2017

Nuria Padilla-Just

2

1 reference

11 September 2017

Ryan E Henry

3

1 reference

11 September 2017

Christopher C Porter

4

1 reference

11 September 2017

Jihye Kim

5

1 reference

11 September 2017

John J Tentler

6

1 reference

11 September 2017

S Gail Eckhardt

7

1 reference

11 September 2017

Aik Choon Tan

8

1 reference

11 September 2017

James DeGregori

9

1 reference

11 September 2017

3 June 2012

1 reference

11 September 2017

Nature Chemical Biology

1 reference

11 September 2017

8

1 reference

11 September 2017

646-654

1 reference

11 September 2017

7

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio.965

11 September 2017

0 references

cites work

The p53 circuit board

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Targeting anaplastic lymphoma kinase in lung cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

The p53 pathway as a target in cancer therapeutics: obstacles and promise

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

MET signalling: principles and functions in development, organ regeneration and cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

ATM activation by oxidative stress

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Drug combination studies and their synergy quantification using the Chou-Talalay method

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Awakening guardian angels: drugging the p53 pathway

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

The combined status of ATM and p53 link tumor development with therapeutic response

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Blinded by the Light: The Growing Complexity of p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Spheroid-based drug screen: considerations and practical approach

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Restoration of p53 function leads to tumour regression in vivo

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Emerging cancer therapeutic opportunities target DNA-repair systems

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Live or let die: the cell's response to p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

PUMA, a novel proapoptotic gene, is induced by p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

PUMA induces the rapid apoptosis of colorectal cancer cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Cooperative effects of genes controlling the G(2)/M checkpoint

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

WAF1, a potential mediator of p53 tumor suppression

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

The role of gastrin in colorectal carcinogenesis.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

BiNGS!SL-seq: a bioinformatics pipeline for the analysis and interpretation of deep sequencing genome-wide synthetic lethal screen.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available cMet kinase inhibitor in human tumor xenograft mouse models

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430605

Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660439

12 December 2020

inferred from PubMed ID database lookup

Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660439

12 December 2020

inferred from PubMed ID database lookup

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660439

12 December 2020

inferred from PubMed ID database lookup

CD40 stimulation sensitizes CLL cells to rituximab-induced cell death

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.965

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.965

1 reference

11 September 2017

1 reference

11 September 2017

1 reference