(Q37247441)

English

Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.

scientific article published on 18 August 2008

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

Europe PubMed Central

Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Christopher L Karp

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

author name string

Daniel W Nebert

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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publication date

18 August 2008

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Europe PubMed Central

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12 January 2020

number of pages

5

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inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

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12 January 2020

283

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

52

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

36061-36065

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Leukotrienes, antileukotrienes and asthma

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Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.

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Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.

1 reference

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Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1.

1 reference

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Physiological regulation of prostaglandins in the kidney

1 reference

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The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice

1 reference

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6 September 2017

Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase

1 reference

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Inflammation and lung carcinogenesis: applying findings in prevention and treatment.

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Structure, biochemistry and biology of hepoxilins: an update

1 reference

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6 September 2017

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems

1 reference

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6 September 2017

Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Oxylipins as developmental and host-fungal communication signals

1 reference

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6 September 2017

Erythrocyte-derived epoxyeicosatrienoic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

1 reference

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6 September 2017

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

1 reference

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6 September 2017

Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

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Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Clinical importance of the cytochromes P450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Large-scale analysis of the human and mouse transcriptomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Cloning of CYP2J2 gene and identification of functional polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Activation of the Ah receptor signaling pathway by prostaglandins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

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Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

1 reference

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6 September 2017

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

6 September 2017

Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans

1 reference

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Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse

1 reference

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Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. I. Stimulation of enzyme activity in nonhepatic cells and in hepatic cells by phenobarbital, polycyclic hydrocarbons, and 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane

1 reference

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Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation

1 reference

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Monoclonal antibody-directed characterization of rat hepatic P450 catalyzing the omega-1 and omega-2 hydroxylation of prostaglandins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

26 June 2018

Lipoxin receptors.

1 reference

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3 September 2018

Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes.

1 reference

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Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation

1 reference

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A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

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Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

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Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

Expression of CYP4F12 in gastrointestinal and urogenital epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2606007

3 September 2018

Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.

1 reference

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3 September 2018

Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid

1 reference

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1 reference

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Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

1 reference

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1 reference

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3 September 2018

Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain

1 reference

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Oxidation of prostaglandin H2 and prostaglandin H2 analogues by human cytochromes P450: analysis of ω-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I1 by mass spectrometry11Abbreviations: CYP, cytochrome P450; HHT, (

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R800053200

21 January 2018

Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoxygenase metabolism of polyunsaturated fatty acids in oocytes of the frog Xenopus laevis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Omega- and (omega-1)-hydroxylation of arachidonic acid, lauric acid and prostaglandin A1 by multiple forms of cytochrome P-450 purified from rat hepatic microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production

1 reference

https://pubmed.ncbi.nlm.nih.gov/18713746

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.R800053200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18713746%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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