(Q37275725)

English

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

scientific article published on 18 October 2013

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scholarly article

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28 February 2020

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B (English)

1 reference

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28 February 2020

apoptotic process

0 references

0 references

1 reference

based on heuristic

inferred from title

chronic lymphocytic leukemia

1 reference

based on heuristic

inferred from title

Spencer B. Gibson

8

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Europe PubMed Central

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28 February 2020

author name string

J-Y Yoon

1

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28 February 2020

D Szwajcer

2

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28 February 2020

G Ishdorj

3

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28 February 2020

P Benjaminson

4

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28 February 2020

W Xiao

5

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28 February 2020

R Kumar

6

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28 February 2020

J B Johnston

7

1 reference

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28 February 2020

publication date

18 October 2013

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28 February 2020

Blood Cancer Journal

1 reference

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28 February 2020

3

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28 February 2020

e153

1 reference

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28 February 2020

Lysosomes and lysosomal cathepsins in cell death

1 reference

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6 September 2017

TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation

1 reference

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6 September 2017

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

1 reference

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6 September 2017

Kinetics of the cell biological changes occurring in the progression of DNA damage-induced senescence

1 reference

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6 September 2017

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

1 reference

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6 September 2017

Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL.

1 reference

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6 September 2017

Ubiquitin: same molecule, different degradation pathways

1 reference

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6 September 2017

Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells

1 reference

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6 September 2017

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Treatment of fludarabine-refractory chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Lysosomal membrane permeabilization in cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Analysis of apoptosis by propidium iodide staining and flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Protein turnover via autophagy: implications for metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

How I treat refractory CLL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Many cuts to ruin: a comprehensive update of caspase substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Lysosomal cysteine proteases: facts and opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

6 September 2017

Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

14 September 2017

Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.

1 reference

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14 September 2017

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

1 reference

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14 September 2017

Lysosomal Acid Hydrolases in Isolated Normal and Chronic Lymphocytic Leukemia (CLL) T- and B-Lymphocytes

1 reference

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14 September 2017

Doxorubicin-induced cell death requires cathepsin B in HeLa cells

1 reference

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26 June 2018

Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis

1 reference

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26 June 2018

Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.

1 reference

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3 September 2018

Stat3 controls lysosomal-mediated cell death in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

3 September 2018

The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3816211

3 September 2018

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis

1 reference

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3 September 2018

Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells

1 reference

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1 reference

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The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

1 reference

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3 September 2018

Histone deacetylase is a target of valproic acid-mediated cellular differentiation

1 reference

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3 September 2018

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1 reference

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3 September 2018

Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia

1 reference

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1 reference

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3 September 2018

CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and isoenzymes of acid phosphatase in human B-cell lymphomas of low-grade malignancy: a novel aid in the classification of malignant lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral valproic acid for epilepsy--long-term experience in therapy and side effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BCJ.2013.50

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Europe PubMed Central

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28 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24141622%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24141622%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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