(Q37299533)

19 August 2017

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase (English)

1 reference

19 August 2017

Opher Gileadi

3

0 references

Ajit Jadhav

object named as

Ajit Jadhav

7

0 references

Anton Simeonov

8

object named as

Anton Simeonov

1 reference

19 August 2017

Andrew S Rosenthal

1

1 reference

19 August 2017

Thomas S Dexheimer

2

1 reference

19 August 2017

Giang H Nguyen

4

1 reference

19 August 2017

Wai Kit Chu

5

1 reference

19 August 2017

Ian D Hickson

6

1 reference

19 August 2017

David J Maloney

9

1 reference

19 August 2017

language of work or name

English

0 references

publication date

13 August 2013

1 reference

Bioorganic & Medicinal Chemistry Letters

19 August 2017

1 reference

19 August 2017

23

1 reference

19 August 2017

20

1 reference

19 August 2017

5660-5666

1 reference

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

RecQ helicases: multifunctional genome caretakers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Premature aging in RecQ helicase-deficient human syndromes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Unwinding the 'Gordian knot' of helicase action.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

The Bloom's syndrome gene product is homologous to RecQ helicases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Reversibility of covalent electrophile-protein adducts and chemical toxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824626

In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct

26 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24012121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24012121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2013.08.025

1 reference

19 August 2017

1 reference

19 August 2017

1 reference